This original story marries three different elements into one plot.
Alex Stokes (Andrew Roth) is a self-destructive, down-on-his-luck investigator who takes cases wherever he can. When a mysterious man offers him a healthy sum to follow his beautiful wife Claire (Melantha Blackthorne), Alex can't resist. Her seemingly mundane day-to-day activities take a strange turn when she tries to kill herself.
First Platoon centers around Rock Brannigan (Scott Gibson) and his ragtag squad of ex-military zombie hunters trying to make a living in the desert Southwest two years after the zombie apocalypse. Along the way, they encounter the grizzled Pa Jericho (Sid Haig), and the eccentric Rex Necro (Malcolm McDowell).
During the 2012 Summer Olympics in London, a virus was released which causes a zombie uprising which decimates humanity. In the year 2018, six years after civilization is destroyed and with few humans left, the King of the Zombies (Noel Fielding) organizes a music festival to keep the zombie horde entertained after the zombie apocalypse.
Gretchen (Sean Serino), a young woman, becomes desperate to contact her brother after his passing. She discovers an amulet that allows her to control the dead—which she uses to try and contact him. The amulet also allows results in the calling forth of a small army of zombies, comedically called "Post-Mortem Americans" in the film. This amulet is a sought after relic, pursued by two feuding vampires who have been at odds for millennia: Vellich (Andrew Divoff) and Sebed (Tom Savini). After encountering the vampires, Gretchen and her friends are joined by the vampire-hunter McCallister (Jason Carter), who had originally stolen the amulet from Vellich. McCallister helps Gretchen and her friends combat the villains, and the film ends with a final showdown between the protagonists and the vampires. The film was called a "vampire-zombie hybrid movie" by the Columbus Dispatch.