Un producteur de cinéma assassine son actrice vedette lors d'un "jeu" érotique et le fait passer pour un suicide. L'amante lesbienne de la fille décédée découvre ce qui s'est passé et prépare sa vengeance.
Georgia prend une colocation chez Salene. Elle ignore alors que cette dernière est une dominatrice professionnelle. Elle ignore aussi que le frère du vétérinaire avec lequel elle a une liaison amoureuse à un frère qui est le meilleur client de Salene.
Ben Cronin (Jesse Bradford) is a star swimmer of his high school's swim team. His coach informs him that Stanford University scouts will appear at next week's swim meet. Ben and his girlfriend Amy (Shiri Appleby) discuss their future plans. Amy has her heart set on going to school in Rhode Island, but explains that she will go to school in California to stay close to Ben. The next day, Ben nearly runs his car into Madison Bell (Erika Christensen) and gives her a ride home as an apology. Later, he realizes that Madison left her notebook in his car. The notebook is filled with music notes, and Ben spots his initials written inside a staff. When he brings the notebook to return it, he meets Madison's cousin, Christopher (James Debello). Madison appears stressed, and explains that she hasn't eaten all day, so Ben offers to take her to dinner. At dinner, Ben tells Madison about his girlfriend, but Madison does not appear too bothered and explains that she has a boy waiting for her in New York City.
Sarah Morton, a middle-aged English mystery author, who has written a successful series of novels featuring a single detective, is having writer's block that is impeding her next book. Sarah's publisher, John Bosload, offers her his country house near Lacoste, France for some rest and relaxation. After becoming comfortable with the run of the house, Sarah's quietude is disrupted by a young woman claiming to be the publisher's daughter, Julie. She shows up one night claiming to be taking time off from work herself. She also claims that her mother used to be Bosload's mistress, but that he would not leave his family.
Retired CIA field operative Bryan Mills attempts to build a closer relationship with his daughter, Kim, who lives with her mother, Lenore, and her wealthy stepfather, Stuart. While overseeing security at a concert for pop star Sheerah, Bryan saves her from a violent stalker. As a thank you, Sheerah offers to assess Kim's talent as a singer. Before Bryan can tell Kim, she asks her father for permission to travel to Paris with her best friend, Amanda. He initially refuses, but eventually agrees after Lenore pressures him. At the airport, he learns the girls are actually following U2 during their European tour, something Lenore knew but kept from him.
Karl Kinsky (Dern) is a mentally ill tattoo artist who is hired to create temporary tattoos for some models. He becomes obsessed with one of them, Maddy (Adams), whom he kidnaps to force her to wear "his mark." He keeps her captive as he creates his masterpiece on her body. Throughout the ensuing captivity, Maddy tries several times to escape, but her attempts are continually thwarted by Kinsky.
Travis Bickle, an honorably discharged U.S. Marine, is a lonely and depressed man in New York City. He becomes a taxi driver to cope with chronic insomnia, driving passengers every night around the boroughs of New York City. He also spends time in seedy porn theaters and keeps a diary. Travis becomes infatuated with Betsy, a campaign volunteer for Senator and presidential candidate Charles Palantine. After watching her interact with fellow worker Tom through her window, Travis enters to volunteer as a pretext to talk to her, and takes her out for coffee. On a later date, he takes her to see a Swedish sex education film, which offends her, and she goes home alone. His attempts at reconciliation by sending flowers are rebuffed, so he berates her at the campaign office, before being kicked out by Tom.
Jodi Lyn O'Keefe reprises Rose McGowan's role in the original film. O'Keefe stars as Debbie Strand, who escapes from the mental institution she was sent off to in the first installment of the series. After the young co-ed dies in an unexpected accident, Debbie steals both the girl's identity and her car, and heads off to the college her victim was supposed to attend. There, Debbie quickly develops a psychotic crush on her dashing writing professor, Dr. Sam Decker, killing anyone she perceives as a threat to their relationship. However, Debbie's scheme starts to fall apart when her roommate begins unraveling Debbie's lies and discovers the truth about her past. Knowing that she is in danger of being exposed, Debbie makes plans to get rid of her roommate and her friends by any means necessary.
Jamie Douglas is a beautiful TV newswoman with a successful career in Los Angeles and a stable relationship with her boyfriend, Brandon. Derek is a psychopathic photographer who stalks her.
Une nuit particulière à Tunis : un jeune homme, Stoufa, révolté et humilié par son père, rencontre une jeune et jolie prostituée, Saloua. Cette fille est violée par ses copains mais c'est sur Stoufa qu'elle se venge. Ce dernier la recherche toute la nuit pour la retenir mais cette fille est introuvable.
Antoine (Michel Blanc) et Monique (Miou-Miou) forment un couple à la dérive malgré l'amour qu'Antoine porte à Monique. Un soir alors qu'ils se trouvent dans un bal, Monique houspille violemment Antoine en lui reprochant sa situation désastreuse, ceux-ci en étant désormais réduits à vivre été comme hiver dans une caravane vétuste.
Une nuit dans le désert du Sinaï, au clair de lune, un groupe d'hommes et de femmes se réchauffe autour d'un feu de camp. Les femmes viennent d'Europe de l'Est, les hommes sont des Bédouins. Demain, ils passeront la frontière en secret et les femmes seront vendues aux enchères. Elles passeront de main en main, victimes d'un réseau de prostitution.