During the summer in Brighton Beach, Brooklyn, elderly widow Sara Goldfarb (Ellen Burstyn) constantly watches television, particularly infomercials hosted by Tappy Tibbons (Christopher McDonald). After receiving an unexpected phone call that she has won a spot to participate on a television game show, she becomes obsessed with regaining the youthful appearance she possesses in an old photograph from her son Harry's (Jared Leto) graduation many years earlier. In order to fit into her old red dress seen in the picture, the favorite one of her deceased husband Seymour, she goes on a crash diet. In order to reach her goal sooner, she goes to a doctor to discuss weight loss. The doctor gives her a prescription for weight-loss amphetamine pills throughout the day and a sedative at night. Harry warns her about amphetamine dependence and risk of life-threatening consequences, but she rebuffs him and insists that the chance to be on television has given her a reason to live. As the months go by, Sara's tolerance for the pills adjust and as a result she is no longer able to feel the same high the pills once gave her. When her invitation has still not arrived, she wrongfully increases her dosage from double to triple and, as a result, begins to suffer from amphetamine psychosis. Soon, her delusions worsen and she is driven to the brink of madness when she suffers a hallucination that she appears on the game show as the principal subject while being attacked by her monstrous, anthropomorphized refrigerator.
At a mental institution, the resident physician, Dr Cohen, encourages his patients who believe they are important Nazi figures to act out their fantasies. The therapy sessions show Hitler consolidating his power by assembling his gang of supporters; however, they are interrupted at times, once because Davidson's uniform is at the dry cleaners, and another time because a patient who believes he is Picasso interrupts a session.
Batman and Robin fail to stop Mr. Freeze from stealing a cache of diamonds. They learn that Freeze was once a scientist named Victor Fries, who became dependent on a diamond-powered subzero suit following an accident in a cryogenics lab while working to save his wife, Nora, from a terminal illness called MacGregor's Syndrome.
A deadly virus wipes out almost all of humanity in 1996, forcing remaining survivors to live underground. In 2027, James Cole (Willis) is a prisoner living in a subterranean shelter beneath the streets of Philadelphia. Cole is selected for a mission, where he is trained and sent back in time to collect information on the virus in order to help scientists develop a cure. Meanwhile, Cole is troubled by recurring dreams involving a foot chase and an airport shooting.
In Gotham City, Batman stops a hostage situation in a bank caused by Two-Face, the alter ego of the disfigured former district attorney, Harvey Dent. However, Two-Face escapes. Edward Nygma, a researcher at Wayne Enterprises, develops a device to beam television directly to a person's brain; Bruce Wayne—with whom Nygma is obsessed—rejects the invention, noting that it "raises too many questions", and Nygma angrily resigns from his position after killing his supervisor Fred Stickley, and forging his suicide note and footage. Everybody except Bruce is convinced it was a genuine suicide. During a news report, it shows how Harvey Dent became Two-Face: While he was prosecuting Sal Maroni, Maroni threw acid in Harvey's face; Batman tried to stop him but failed. After meeting Batman-obsessed psychiatrist Dr. Chase Meridian, Bruce invites her to a charity circus event. There, Two-Face and his henchmen storm the event in an attempt to discover Batman's secret identity, and in the process murder The Flying Graysons, a family of acrobats who attempt to stop him. The youngest member, Dick, survives and throws Two-Face's bomb into the river to detonate safely underwater but the rest of the family dies.
Psychiatrist Jack Mickler (Marlon Brando) dissuades a would-be suicide—a 21-year-old, costumed like Zorro and claiming to be Don Juan (Johnny Depp), who is then held for a ten-day review in a mental institution. Mickler, who is about to retire, insists on doing the evaluation and conducts it without medicating the youth. "Don Juan" tells his story—born in Mexico, the death of his father, a year in a harem, and finding true love (and being rejected) on a remote island. Listening enlivens Mickler's relationship with his own wife, Marilyn (Faye Dunaway). As the ten days tick down and pressure mounts on Mickler to support the youth's indefinite confinement, finding reality within the romantic imagination becomes Jack's last professional challenge.
Alcoholic Cleveland housewife Cassie Barrett is institutionalized in a psychiatric ward after experiencing a nervous breakdown in the supermarket. We learn this is the latest in a series of hospitalizations from which Cassie emerges supposedly in control of her life but actually still teetering on the edge. During this latest stay, she develops a romantic crush on psychiatrist Edwin Alexander and a close relationship with night supervisor Tinkerbell, both of whom help her take steps toward facing her inner demons and learning to live with sobriety.
Aura (Asia Argento), a young woman suffering from anorexia escapes from a psychiatric hospital and meets a young man, David (Christopher Rydell), who offers to let her stay with him rather than go back to the hospital. However, Aura is soon caught, but her return to the hospital coincides with the start of a string of murders of hospital staff members, past and present. The killer decapitates them using a home-made garrote device on rainy days. When her father is murdered along with her mother, Aura and David team up to find the killer.
À 25 ans, Martine (Valeria Bruni Tedeschi) en a marre des aventures courtes. Après une dispute, elle devient amnésique et doit être envoyée dans un hôpital psychiatrique. Là-bas, elle change et devient active et attentionnée.
In 1978, narcissistic, manipulative Madeline Ashton performs in a musical on Broadway. Madeline invites long-time rival Helen Sharp, an aspiring writer, backstage along with her fiancé, plastic surgeon Ernest Menville. Ernest is smitten with Madeline, soon breaking off his engagement with Helen to marry her. Seven years later, Helen is in a psychiatric hospital after fixating upon Madeline. Obese and depressed, Helen feigns rehabilitation and is released, plotting revenge on Madeline.
When Dr. Peter Morgan (Kiefer Sutherland) begins his medical internship at a Veteran's Administration hospital, he expects to breeze through on his way to a cushy practice. Instead, he's thrust into a bizarre bureaucratic maze where the health of patients is secondary to politics. And the temperature really rises when he teams up with some freewheeling physicians, led by Dr. Richard Sturgess (Ray Liotta), who think they've learned how to break the rules-and save lives-without getting caught.
In 1995, John Connor is ten years old and living in Los Angeles with foster parents. His mother Sarah Connor had been preparing him throughout his childhood for his future role as the leader of the Human Resistance against Skynet, but was arrested after attempting to bomb a computer factory and imprisoned at a mental hospital under the supervision of Dr. Silberman. Skynet sends a new Terminator, designated as T-1000, back in time to kill John. The T-1000 is an advanced prototype composed of a mimetic polyalloy that allows it to take on the shape and appearance of almost anything it touches, and transform parts of its anatomy into knives and other stabbing weapons. The T-1000 arrives under a freeway, kills a policeman and assumes his identity. Meanwhile, the future John Connor has sent back a reprogrammed T-800 (Model 101) Terminator to protect his younger self.