Billy Breedlove (Beau Bridges) is an orderly at a Texas psychiatric hospital. He simultaneously falls under the spell of two people: a blonde waitress at a local diner named Jimmie Jean Jackson (Elizabeth Taylor) and an allegedly sociopathic hospital patient named Hammersmith (Richard Burton), who is restrained in a straitjacket within a locked cell.
Berlin techno DJ and producer Martin Karow (nicknamed Ickarus) is touring the techno clubs of the world with his girlfriend Mathilde while working on a new studio album that he plans to release soon. In order to be able to work and party day and night, Ickarus takes all kinds of drugs, mainly supplied by his friend Erbse at the clubs in Berlin. After consuming a PMA-containing ecstasy tablet, Ickarus goes into a drug-induced psychosis, eventually finding himself naked in a Berlin hotel where his antics attract the attention of the hotel staff. He is taken to a psychiatric hospital in Berlin, which puts his album and upcoming live performances in danger.
In 1978, Mary Mattock has her first period, and due to menstrual psychosis, murders her parents with a hatchet. Deemed mentally unfit, Mary is placed in Kings Park Psychiatric Center, where she is raped and impregnated by a guard in 1989. This incident is covered up, and after being told her child was a stillbirth, Mary goes on a rampage through the hospital. The police find Mary wandering the grounds, and open fire on her after she throws the severed head of her rapist at them, ending her killing spree. "Mary Hatchet" subsequently becomes a folklore figure, with local youngsters celebrating the Mischief Night-esque "Blood Night" in her name.
Alcoholic Cleveland housewife Cassie Barrett is institutionalized in a psychiatric ward after experiencing a nervous breakdown in the supermarket. We learn this is the latest in a series of hospitalizations from which Cassie emerges supposedly in control of her life but actually still teetering on the edge. During this latest stay, she develops a romantic crush on psychiatrist Edwin Alexander and a close relationship with night supervisor Tinkerbell, both of whom help her take steps toward facing her inner demons and learning to live with sobriety.
Chandru (Pratap K. Pothen), the managing director of an export company in Bangalore, has a hatred for prostitutes since childhood, as he was the victim of a prostitute who ruined his family by taking his father away from his mother. Raghunath (N. Viswanathan) is a police inspector who knows Chandru and his mother. Raghunath's son Ravi (Bhanu Chander) is engaged to Rekha (Shoba).
Une jeune femme (Carole Bouquet) tente de se prouver en permanence qu'elle est en vie. Au point d'accomplir des actes qui paraissent étranges à son entourage et d'être considérée comme folle…
Vinod (Mohanlal) becomes mentally ill after his girlfriend Anitha (Lizy) dies because of an electric short circuiting accident during a rock concert. Vinod is admitted into an institution managed by Dr. Ravindran (M. G. Soman).
Zelal is an invitation to delve into the world of psychiatry and "madness" in Egypt. It meets the ordinary madmen and women banished to mental institutions by Egyptian society and offers more than just a journey into their world of shadows. The hospitals end up becoming the only place patients can conceive, not because they are truly "crazy", but because they fear the outside world. The film forces viewers to put their own preconceptions and interpretations to the test, reminding us that freedom is precarious in a society that does not tolerate any differences.
Dr. Derrick Russell (Malcolm McDowell) rapes one of the patients in his care. When she throws herself from the roof shortly afterward, he describes her suicide as a consequence of her depression. Ten years later, he plans to rape another patient, Sandy Ramirez (Pamela Gidley). What Russell does not know is that Sandy is the daughter of his previous victim, and that she is bent on revenge. A post-credit sequence depicts a man kissing the camera before he laughs.
Mason Crane, a one-handed man who went on a murderous rampage after committing familicide, is set to be moved from one section of a Woodland Heights psychiatric hospital to another. As soon as Mason's cell is opened, the deranged man crushes an orderly with the door, cuts another's skullcap off with a clipboard, and escapes. Mason makes his way to a wilderness-adjacent home, where he kills a dog, and replaces his missing hand with a bent two-pronged grilling fork. With his new weapon, Mason attacks a group of children playing in a cemetery, stabbing one to death, and scattering the rest.
Timofyev (Malcolm McDowell) is a patient in an asylum who claims to be the man who killed Tsar Alexander II in 1881, and his grandson Tsar Nicholas II in 1918.
While serving at a dinner party kitchen maid Augustine (Soko) feels her hands going numb and then has a violent fit that leaves her paralyzed in one eye. Augustine is brought to a hospital where she attracts the attention of Jean-Martin Charcot (Vincent Lindon) after she seizures in front of him. Charcot examines her while she is naked and realizes that she has lost feeling in one side of her body. He pierces her arm with a hot needle but Augustine cannot feel it. He also discovers that despite having matured physically, Augustine has never menstruated.