Timofyev (Malcolm McDowell) is a patient in an asylum who claims to be the man who killed Tsar Alexander II in 1881, and his grandson Tsar Nicholas II in 1918.
Ricky, a 23-year-old psychiatric patient, has been deemed cured and is released from a mental institution. Until then he has been the lover of the woman director of the hospital. An orphan, free, and alone, his goal is to have a normal life with Marina Ozores, an actress, former porn star, and recovering drug addict, whom he once slept with during an escape from the asylum.
In 1969, Dr. Malcolm Sayer (Robin Williams) is a dedicated and caring physician at a local hospital in the New York City borough of The Bronx. After working extensively with the catatonic patients who survived the 1917–1928 epidemic of encephalitis lethargica, Sayer discovers certain stimuli will reach beyond the patients' respective catatonic states; actions such as catching a ball, hearing familiar music, and experiencing human touch all have unique effects on particular patients and offer a glimpse into their worlds. Leonard Lowe (Robert De Niro) proves elusive in this regard, but Sayer soon discovers that Leonard is able to communicate with him by using a Ouija board.
Emory Leeson is an advertising executive who experiences a nervous breakdown. He designs a series of "truthful" advertisements, blunt and bawdy and of no use to his boss Drucker's firm.
Dr. Derrick Russell (Malcolm McDowell) rapes one of the patients in his care. When she throws herself from the roof shortly afterward, he describes her suicide as a consequence of her depression. Ten years later, he plans to rape another patient, Sandy Ramirez (Pamela Gidley). What Russell does not know is that Sandy is the daughter of his previous victim, and that she is bent on revenge. A post-credit sequence depicts a man kissing the camera before he laughs.
Mason Crane, a one-handed man who went on a murderous rampage after committing familicide, is set to be moved from one section of a Woodland Heights psychiatric hospital to another. As soon as Mason's cell is opened, the deranged man crushes an orderly with the door, cuts another's skullcap off with a clipboard, and escapes. Mason makes his way to a wilderness-adjacent home, where he kills a dog, and replaces his missing hand with a bent two-pronged grilling fork. With his new weapon, Mason attacks a group of children playing in a cemetery, stabbing one to death, and scattering the rest.
Tim Doolan (Horovitz), a troubled youth from a broken home in Los Angeles, is sent to a private psychiatric hospital after an altercation with the police turns violent. In the hospital, he makes a connection with Dr. Charles Loftis (Sutherland), a man with issues of his own.
Babu is a care-taker in a mental hospital who shows much devotion to his job unlike other employees and more affection towards the patients in the hospital. He wears the patients' dress and moves with them like one among them. Due to this nature the Chief Doctor, also a priest Father, likes him very much than others fetching Babu the enmity of two compounders in the hospital. One of the financial donors of the hospital brings a wandering girl to hospital suspecting that she is mentally ill. Since nobody knows about her anything and she is a mentally challenged the hospital admits her. Babu moves with the girl like he moves with all other patients but shows more affection than others as she does not have anybody to take care. The employees watch with curiosity and spin stories on them. Babu names the girl as Meenakshi and calls her Meenu. One of the two compounders tries to rape a mentally challenged girl and Meenu makes snake alert to stop it which fetches everybody. This angers the compounder and he gives electric shock. Babu rescues Meenu and complains to Father resulting in the suspension of the compounder and his friend. Babu now makes more care for her and spends more time with her.
One year after the events of the second film, Kristen Parker is scolded by her mother Elaine to go to bed after staying up all night making a papier-mâché house. Kristen objects but obeys her mother. As she dreams, she is stalked in her model, which is revealed to be 1428 Elm Street, the home of Nancy Thompson and Jesse Walsh. Running from him, she wakes up in her own bed again and realizes it was a dream. The stalker, who is revealed as Freddy Krueger, then appears to her when she goes to wash her face and proceeds to slash her wrists with his claws. Elaine walks in, and Freddy makes the attack appear as a suicide attempt and has her admitted to the hospital for help. Going into hysterics after an attempt to sedate her, Kristen is calmed when Nancy Thompson, a newly hired member of the hospital staff arrives and earns her trust by finishing Freddy's nursery rhyme.
The staff and patients go about their daily business at Buenos Aires' José Borda Psychiatric Hospital on a summer day in 1985. A staff psychiatrist, Dr. Julio Denis (Lorenzo Quinteros) is surprised to hear that his ward for non-violent delusional cases has one patient too many. Denis finds him in the chapel playing the organ like a virtuoso. Summoning him (Hugo Soto) to his office, Denis finds the man's speech is measured and articulate as he explains his presence there as a result of an image being projected from light years away. He introduces himself as "Rantés" (an exotic sounding name in Argentina). Dr. Denis is convinced that Rantés is a fugitive hoping to hide from the law in the hospital. He lets the patient stay however, after seeing how his caring touch helps the other patients. The doctor is amused by his extraterrestrial claims and he suspects that the man is a genius using his talents as a charade.
The sequel picks up on Christmas Eve some years after the first one, with Ricky Caldwell, the 18-year-old brother of the first film's killer, is now being held in a mental hospital, awaiting trial for a series of murders that he committed. While being interviewed by the psychiatrist Dr. Henry Bloom, Ricky tells the story of the murders his brother Billy committed throughout a series of several flashbacks used footage from the original film, as well as some new shots inserted in the flashbacks to make Ricky appear in more of Billy's original story.
Shekar (Prabhu) becomes mentally ill after his girlfriend Anita (Lizy) dies because of an electric short circuiting accident during a rock concert. Shekar is admitted into an institution managed by Nagaraj (Senthamarai).
Vinod (Mohanlal) becomes mentally ill after his girlfriend Anitha (Lizy) dies because of an electric short circuiting accident during a rock concert. Vinod is admitted into an institution managed by Dr. Ravindran (M. G. Soman).
Mike Strauber, a businessman with a history of mental illness, walks in on his wife, Sharon, having sex with Jerry, his best friend. Mike storms off, and wanders aimlessly as he contemplates suicide while flashing back to his time with Sharon, and a childhood incident where he cut himself with a razor while playing Truth or Dare? Mike picks up a female hitchhiker, and the two go to a campsite, where they play Truth or Dare? The game turns violent, and ends when a park ranger finds Mike, who had mutilated himself at the behest of the hitchhiker, who was just a hallucination.