Dr. Bela Reinhardt (Ron Chaney) is a mad doctor who has invited five people to his castle to determine which of them shall inherit his estate. He has arranged for a competition of sorts. The winner will be chosen by process of... elimination.
Stan Helsing (Steve Howey) is an underachieving employee at a video rental store named Schlockbuster whose personal mottos are "Don't get involved" and "Don't talk about it". His teen-aged boss Sully orders him to drop off a bag of movies to the mother of the store's owner or risk not having a job Monday morning. Despite his arguments, he agrees to the request and manages to get his friend Teddy (Kenan Thompson), his ex-girlfriend Nadine (Diora Baird) and ditsy blond massage therapist Mia (Desi Lydic) to take him there before they attend a Halloween party, even though it's on the other side of town.
In a typical Tokyo high school a perpetually teenage vampire named Monami (Yukie Kawamura) falls for her classmate, Mizushima (Takumi Saito), who happens to already be the reluctant boyfriend to the vice principal/science professor's daughter, Keiko (Eri Otoguro), a leader of a Sweet Lolita gang. The ensuing love triangle leads Keiko to seek the assistance of her father who, unbeknown to his daughter, moonlights as a Kabuki-clad mad scientist with the school nurse as his assistant. The pair experiment on students in the school basement hoping to discover the secret of reanimating corpses (akin to the work of Victor Frankenstein). Their hopes are answered when they discover a solution of Monami's blood holds the properties to bring life to dead body parts and inanimate objects.
The Kingdom of Malaria's environment is devastated by a mysterious storm. Its king, Malbert, then blackmails the rest of the world to pay the town not to unleash the various doomsday devices invented by its Evil Scientists. They in turn are assisted by Igors, while the kingdom's annual Evil Science Fair showcases the scientists' latest weapons. One Igor, however, who serves the somewhat tedious-minded Doctor Glickenstein, is a talented inventor who aspires to be an Evil Scientist himself. Among his inventions are his friends "Scamper," a re-animated, immortal rabbit with a death wish and "Brain," a unintelligent human brain transplanted into a life support jar.
Dr. Victoria Frankenstein, a scientist experimenting on stem cells and biotechnology, is working to advance medical science so her eight-year-old child, William, has a chance to receive organ transplants, and possibly a cure. This is the Universal Xenograft Project, overseen by Professor Andrew Waldman and assisted by her friend, Ed Gore. In the process of an organ-growing experiment, Victoria inserts William's blood into the procedure, and the stem cells begin to grow at a rapid rate. The insertion of William's blood is unknown until Ed discovers a tooth within the purpose built tank in which the stem cells are cultivating, and Andrew is then alerted. X-rays within the tank show that an organism is growing, and for the intention of scientific advancement, it is allowed to live. However, a lightning strike cuts the power within the building, and the creature, referred to as "the UX", escapes.
Mad Doctor Monroe Lazaroff seeks to create a biological "terror weapon" in a secluded beach house. His first creation is an amphibious Creature, created by mixing human, fish and reptile DNA. This Creature turns against its creators and escapes into the nearby ocean and soon is terrorizing those who venture onto its beach territory in Blood Cove.
In 1887, Transylvanian Doctor Victor Frankenstein brings to life his Monster with the aid of his assistant Igor and Count Dracula. After Dracula betrays and kills Doctor Frankenstein, the Monster escapes to a windmill, which is burned down by a pursuing mob. The mob flees as Dracula and his three brides mourn the loss of the Monster.
This is not a direct adaptation of the Mary Shelley novel, but a postmodern gothic reinvention set in present-day New Orleans. It recasts the doctor as the villain and the creature as a tragic hero determined to stop him; the primary action involves two police detectives (Parker Posey and Adam Goldberg) who enlist the aid of the creature ("Deucalion" in this version) to stop a serial killer who is one of Victor's later creations.
Captain Robert Walton is a failed writer who sets out to explore the North Pole and expand his scientific knowledge in hopes of achieving fame. During the voyage the crew spots a dog sled mastered by a gigantic figure. A few hours later, the crew rescues a nearly frozen and emaciated man named Victor Frankenstein. Frankenstein has been in pursuit of the gigantic man observed by Walton's crew. Frankenstein starts to recover from his exertion; he sees in Walton the same over-ambitiousness and recounts a story of his life's miseries to Walton as a warning.
The Chipmunks are performing at a theme park called Majestic Movie Studios (a spoof of Universal Studios Hollywood). While taking a break from their concert, the Chipmunks get lost, and eventually get locked inside the park. They find their way to the "Frankenstein's Castle" attraction, where a real Dr. Victor Frankenstein is working on his monster. The monster is brought to life, and the doctor sends it in pursuit of the Chipmunks. In their escape, the monster retrieves Theodore's dropped teddy bear.
The story opens in the 1950s, after the Korean War; it has been more than a decade since James Whale, director of Frankenstein and Bride of Frankenstein, has retired. He lives with his long-time housemaid, Hanna, who loyally cares for him but disapproves of his homosexuality. Whale has suffered a series of strokes that have left him fragile and tormented by memories: growing up as a poor outcast, his tragic World War I service, and the filming of The Bride of Frankenstein. Whale slips into his past, and indulges in his fantasies, reminiscing about gay pool parties and also sexually teasing an embarrassed, starstruck fan who comes to interview him. Whale battles depression, at times contemplating suicide, as he realizes his life, his attractiveness, and his health are slipping away.
Moira Frankenstein (Lina Romay), la fille du défunt professeur, découvre la "déesse" (Michelle Bauer), une créature féminine créée par son père. Fascinée, elle n'a plus qu'une idée en tête : trouver de jeunes filles pour contenter la créature.