This is not a direct adaptation of the Mary Shelley novel, but a postmodern gothic reinvention set in present-day New Orleans. It recasts the doctor as the villain and the creature as a tragic hero determined to stop him; the primary action involves two police detectives (Parker Posey and Adam Goldberg) who enlist the aid of the creature ("Deucalion" in this version) to stop a serial killer who is one of Victor's later creations.
Captain Robert Walton is a failed writer who sets out to explore the North Pole and expand his scientific knowledge in hopes of achieving fame. During the voyage the crew spots a dog sled mastered by a gigantic figure. A few hours later, the crew rescues a nearly frozen and emaciated man named Victor Frankenstein. Frankenstein has been in pursuit of the gigantic man observed by Walton's crew. Frankenstein starts to recover from his exertion; he sees in Walton the same over-ambitiousness and recounts a story of his life's miseries to Walton as a warning.
Dr. Victoria Frankenstein, a scientist experimenting on stem cells and biotechnology, is working to advance medical science so her eight-year-old child, William, has a chance to receive organ transplants, and possibly a cure. This is the Universal Xenograft Project, overseen by Professor Andrew Waldman and assisted by her friend, Ed Gore. In the process of an organ-growing experiment, Victoria inserts William's blood into the procedure, and the stem cells begin to grow at a rapid rate. The insertion of William's blood is unknown until Ed discovers a tooth within the purpose built tank in which the stem cells are cultivating, and Andrew is then alerted. X-rays within the tank show that an organism is growing, and for the intention of scientific advancement, it is allowed to live. However, a lightning strike cuts the power within the building, and the creature, referred to as "the UX", escapes.
Boris Karloff plays the role of Baron Victor von Frankenstein, who suffered torture and disfigurement at the hands of the Nazis as punishment for not cooperating with them during World War II. Horribly disfigured, he nevertheless continues his work as a scientist. Needing funds to support his experiments, the Baron allows a television crew to shoot a made-for-television horror film about his monster-making family at his castle in Germany.
All of the women on the planet Mars have died in an atomic war, except for Martian Princess Marcuzan (Marilyn Hanold). Marcuzan and her right-hand man, Dr. Nadir (Lou Cutell), decide they will travel to Earth and steal all of the women on the planet in order to continue the Martian race. The Martians shoot down a space capsule manned by the android Colonel Frank Saunders (Robert Reilly), causing it to crash in Puerto Rico. Frank's electronic brain and the left half of his face are damaged after encountering a trigger-happy Martian and his ray gun. Frank, now "Frankenstein", described by his creator as an "astro-robot without a control system" proceeds to terrorize the island. A subplot involves the martians abducting bikini clad women.
Years later, Hans Werner (Robert Morris) is working as an assistant to Baron Victor Frankenstein (Peter Cushing), helped by Dr Hertz (Thorley Walters) who is in the process of discovering a way of trapping the soul of a recently deceased person. Frankenstein believes he can transfer that soul into another recently deceased body to restore it to life.
Baron Victor Frankenstein (Cushing) is housed at an insane asylum where he has been made a surgeon at the asylum, and has a number of privileges, as he holds secret information on Adolf Klauss, the asylum's corrupt and perverted director (John Stratton). The Baron, under the alias of Dr. Carl Victor, uses his position to continue his experiments in the creation of man.
Herman Munster (Fred Gwynne) and his wife, Lily (Yvonne De Carlo) learn from Cavanaugh Munster's will that they have inherited an English manor known as Munster Hall in Shroudshire, England, and that Herman has inherited the designation Lord Munster. The family boards the SS United States to England. Herman gets seasick, Marilyn (Debbie Watson) encounters Roger Moresby (Robert Pine), and Grandpa (Al Lewis) gets turned into a wolf upon accidentally consuming a wolf pill. Grandpa is sneaked through customs.
Bob, chirurgien, arrière-petit-fils du Baron Frankenstein, a dissimulé son laboratoire dans le sous-sol de l’hôpital pour continuer les travaux de son illustre ancêtre. Avec son fidèle Iggy, il essaie de rassembler des morceaux de corps humains en vue de créer son propre “monstre”.
When a hot air balloon crashes on a remote and uncharted island, the four balloonists and their dog Melvin are captured by a pair of drunken old pirates who take them to the hilltop laboratory home of Dr. Frankenstein's modern-day descendant Sheila Frankenstein (Katherine Victor) who is carrying on the family tradition by turning shipwrecked sailors into pre-programmed bloodless, black-garbed zombies who must wear sunglasses to protect their weird white eyes from light.
Dr. Frederick Frankenstein (Gene Wilder) is a physician lecturer at an American medical school and engaged to the tightly wound socialite Elizabeth (Madeline Kahn). He becomes exasperated when anyone brings up the subject of his grandfather, the infamous mad scientist. To disassociate himself from his forebear, Frederick insists that his surname is pronounced "Fronkensteen."
The film centers around the life of Victor Frankenstein. After creating the monster together with his partner Zuckel, the monster attacks the assistant and falls from a cliff. Assuming the monster is dead, Victor returns to his wife Elizabeth and daughter Emily. A police inspector named Bellbeau investigates some mysterious mutilations killings, and Victor is blackmailed by his former assistant, who lost an eye in his fight with the monster.