A British agent carrying a vital document is murdered on his way to deliver it in the USA. Holmes deduces he was carrying the document in the form of microfilm and goes to Washington with Watson to find the killer and retrieve the document before it falls into the hands of an "international spy ring". Before his death, the agent managed to pass the microfilm into the unwitting hands of a Washington debutante and bride-to-be. There are some amusing moments when the microfilm, which has been inserted into a "V for Victory" matchbook, gets passed from hand to hand at a party unknowingly, and at one point is discarded by the chief criminal. Holmes and Watson track down the criminals, rescue the bride-to-be and regain the microfilm.
Sherlock Holmes (Basil Rathbone) pretends to be a Nazi spy to aid scientist Dr. Franz Tobel (William Post Jr.) and his new invention, a bombsight, in escaping a Gestapo trap in Switzerland. Holmes and Franz fly to London, where Holmes places him under the protection of his friend, Dr. Watson (Nigel Bruce). The scientist slips away against Holmes' instructions for a secret reunion with his fiancee, Charlotte Eberli (Kaaren Verne), and gives her an envelope containing a coded message. He tells Charlotte to give it to Holmes if anything should happen to him. Leaving Charlotte's apartment, an attempt to abduct him by German spies is foiled by a passing London bobby.
The film begins with a title card describing Holmes and Watson as "ageless", as an explanation as to why the film is set in the 1940s rather than Holmes' era of 1881–1914, as the preceding 20th Century Fox films were. Though there is a nod to the classic Holmes in a scene where Holmes and Watson are leaving 221b Baker Street, and Holmes picks up his deerstalker. Watson protests, and Holmes reluctantly puts on a fedora instead.
Sherlock Holmes (Basil Rathbone) and Dr. John Watson (Nigel Bruce) receive a visit from Dr. James Mortimer (Lionel Atwill), who wishes to consult them before the arrival of Sir Henry Baskerville (Richard Greene), the last of the Baskervilles, heir to the Baskerville estate in Devonshire.
The film begins with Moriarty and Holmes verbally sparring on the steps outside the Old Bailey where Moriarty has just been acquitted on a charge of murder due to lack of evidence. Holmes remarks, "You've a magnificent brain, Moriarty. I admire it. I admire it so much I'd like to present it, pickled in alcohol, to the London Medical Society". "It would make an impressive exhibit", replies Moriarty.
Sherlock Holmes takes a holiday by visiting his old friend Sir Henry Baskerville (Lawrence Grossmith). Sherlock's vacation ends when he and Dr. Watson suddenly find themselves in the middle of a double-murder mystery. Now they have got to find Professor Robert Moriarty (Lyn Harding) and the horse, Silver Blaze before the great cup final horse race and bring the criminals to justice.
L'action débute lors d'un banquet au manoir de Sir Hugo Baskerville. La scène illustre la cruauté de Sir Hugo qui, en pleine réception, tue dans un duel à l'épée un invité, Sir Bettans, qui avait courtisé sa femme. Alors que Sir Hugo va s'en prendre à cette dernière, un chien surgit et attaque le maître de maison, le mettant hors d'état de nuire.
Detective Morris Flynn (Hans Albers) and his assistant Macky McMacpherson (Heinz Rühmann), masquereading as Sherlock Holmes and Dr Watson, investigate two attractive sisters, Mary and Jane Berry, and the theft and forgery of valuable postage stamps.
Sherlock Holmes and Dr. Watson come out of retirement to investigate a mysterious murder. They find that an American criminal organisation called The Scowrers has asked evil mastermind Professor Moriarty to wreak vengeance on John Douglas, the informant who sent them to prison. Holmes outsmarts Moriarty, solves the murder and brings Moriarty to justice.
Les membres d'une société secrète londonienne succombent les uns après les autres dans de mystérieuses circonstances. Lorsque vient le tour du richissime Sir James Murphy, sa veuve désespérée fait appel aux services du détective Sherlock Holmes pour qu'il découvre ce qu'il est advenu de la fortune de son défunt mari...
Le film débute à Londres, où le professeur Moriarty (Ernest Torrence) vient d'être arrêté grâce à la perspicacité de Sherlock Holmes (Clive Brook). Au tribunal, Moriarty prononce un discours dans lequel il promet que les trois personnes impliquées dans sa condamnation mourront avant lui : le juge Erskin, le colonel Gore-King et Sherlock Holmes. Pendant ce temps, Holmes prévoit de commencer une nouvelle vie à la ferme avec sa fiancée Alice Faulkner.
Jonathan Small, a prisoner serving a lengthy sentence on the Andaman Islands cuts a deal with two army officers, Major Sholto and Captain Morstan, in command of the prison. He reveals the location of a stash of loot in exchange for their help in helping him to escape from jail. The proceeds are to be split equally between the three of them.