In 1947, the long-retired Sherlock Holmes, aged 93, lives in a remote Sussex farmhouse with his housekeeper, Mrs Munro, and her young son Roger. Having just returned from a trip to Hiroshima, he starts to use jelly made from the prickly ash plant he acquired there in an effort to improve his failing memory. Unhappy about his ex-partner Watson's fictionalisation of the story of Holmes's last case, the fictitious “The Adventure of the Dove Grey Glove”, he hopes to write his own account but is having trouble recalling the details. As Holmes spends time with Roger, showing him how to take care of the bees in the farmhouse's apiary, he comes to appreciate Roger's curiosity and intelligence and develops a paternal liking for him.
Des meurtres semblables à ceux attribués à Jack l'Éventreur sont commis à Madrid. Holmes (Gary Piquer), qui est sujet à des rêves prémonitoires au cours desquels il entrevoit la survenue de ces meurtres, décide de se rentre à Madrid pour enquêter sur l'affaire en compagnie du Docteur Watson (José Luis García Pérez) marié depuis peu à Mary Morstan (Leticia Dolera).
In 1891, Irene Adler delivers a package to Herr Dr. Hoffmanstahl; payment for a letter he was to deliver. Hoffmanstahl opens the package, triggering a hidden bomb that is prevented from detonating by the intervention of Sherlock Holmes. Holmes takes the letter while Adler and Hoffmanstahl escape. Holmes finds Hoffmanstahl assassinated moments later. Adler meets with Professor Moriarty to explain the events, but Moriarty poisons and kills her — deeming her position compromised by her love for Holmes.
In London, an unseen criminal begins masterminding his "perfect plot on paper" which starts with a robbery taking place and three cats stealing a pink diamond. Three constables spot them and give chase, but the cats escape to the rooftops and glide off into the night, giving the stolen diamond to a mysterious horseman. The next day Dr. Watson rushes to 221B in Baker Street and informs his colleague Sherlock Holmes of the robbery. Holmes calls Jerry Mouse to bring him a copy of the Times. Jerry heads out to buy it, bumping into Tom Cat on the way, who has something for Holmes. Jerry sends a pile of bricks on Tom and Tom gives chase. Jerry returns to Holmes' flat and hands him the paper or what was left of it after the chase. Reading a letter Tom had given to them, for the night, Holmes and Watson decide to go to the Bruce Nigel Theatre and see a lady named Red. Holmes is told that she is being blackmailed and Holmes suggests the perpetrator might be - Professor Moriarty. Holmes deduces that the Star of Punjab, a diamond that is sensitive to the light of a solar eclipse which was to happen the following day, is to be stolen by the mastermind of the blackmail.
The film begins during the German air raids in London in 1940. An elderly Dr. John Watson tells his nurse the tale of an unrecorded case he shared with his friend Sherlock Holmes. In 1882, Holmes and Watson investigate a ship carrying gold which was reportedly destroyed by a monstrous giant octopus on the coast of Newhaven. They do not believe the first-hand accounts of the sole survivor of the attack, but nonetheless investigate. Holmes is informed by Inspector Lestrade that he has recently had contact with Holmes's estranged brother Thorpe, a former partner of Lestrade's who was paralyzed during a bank robbery seven years prior.
In 1891, London detective Sherlock Holmes (Robert Downey, Jr.) and his partner and flatmate Dr. John Watson (Jude Law) race to prevent the ritual murder of a woman by Lord Blackwood (Mark Strong), who has killed five other young women similarly. They stop the murder before Inspector Lestrade (Eddie Marsan) and the police arrive to arrest Blackwood.
The Baker Street Irregulars investigate as several of their members go missing, while also trying to prevent Sherlock Holmes — who is undergoing a personal crisis — being convicted of murder.
Sherlock Holmes and Dr. Watson are called to Whitechapel after learning about a series of strange murders only two years after the Jack the Ripper murders in the same neighborhood. The local belief is that the killings are the work of a vampire brought back from a recent mission in Guyana. As they investigate the deaths, they engage in an ongoing debate about the supernatural, with Watson believing in the possibility of vampires and Holmes remaining skeptical until he is able to prove the murders are the works of a living human, rather than any undead creature. At one point, the investigation leads them to the psychic Madame Karasky, who says that Holmes will be saved by the church. Shortly thereafter, Holmes is pushed in front of a moving carriage by the supposed vampire, only to be saved by a pedestrian. In order to catch the murderer, Holmes disguises himself as a monk and reveals that the vampire was Brother Abel, who hoped to get revenge on the monks who didn't listen to him when he believed that the bats were causing rabies in the South American mission, when he was infected. The film ends at Baker Street, when Mrs. Hudson gives Holmes his pipe, delivered by the same man that saved Holmes from being run over. When Holmes asks his name, Mrs. Hudson says his name was Reginald Church.
As the movie opens, Sherlock is in pursuit of the criminal Professor Moriarty (Vincent D'Onofrio) and apparently shoots him to death. His body cannot be found, however, as it falls in a sewer. After this incident, Holmes gains notoriety with the press and the police for his apparent killing of Moriarty, and meets Dr. Watson (Roger Morlidge), an early practitioner of autopsies, for the first time. Together, they start an investigation into the murder of several crime lords and become convinced that Moriarty is alive and behind a plot to organize drug dealing. Given that Moriarty is supposedly dead, Holmes finds it hard to convince Inspector Lestrade (Nicholas Gecks) of this claim. Holmes' investigation leads him to a prostitute (Gabrielle Anwar), who posed as a rich woman to lure Holmes into the plot. Richard E. Grant also appears as Holmes' brother, Mycroft, who was addicted to opium by Moriarty when Sherlock was young.
Rio de Janeiro, 1886. Actress Sarah Bernhardt performs at the city's Municipal Theater, captivating the local audience enthralled by French culture. The city is at her feet, and even the Emperor Pedro II comes to pay his respects. He confides a secret to her: the disappearance of a precious Stradivarius violin presented by him to the charming widow Baroness Maria Luiza. The actress suggests to the monarch to hire her friend, the legendary British detective Sherlock Holmes, to solve the case. Subsequently, a brutal murder shocks the city, and leaves the police superintendent Mello Pimenta: a prostitute had been killed and mutilated, her ears cut off and a violin cord strategically placed on her body by the perpetrator. Later, under the heat of the tropical sun, the lives of Holmes and Doctor Watson are changed forever, as they find themselves neck-deep in a cultural milieu that portrays all standard Brazilian stereotypes.
Sherlock Holmes enquête sur une affaire de chantage, mêlant le prince héritier de Bohême, une princesse scandinave et une talentueuse chanteuse d'opéra...
Mary Morstan reçoit une perle de toute beauté chaque année de la part d'un inconnu. Lors du dernier envoi, cette personne demande à la rencontrer. Elle demande l'aide de Sherlock Holmes et du Docteur Watson. Ils vont se trouver mêlés à une histoire de terrible vengeance…