Renfield, a solicitor, makes a journey into Transylvania via stagecoach. He mentions his destination, Castle Dracula, to the locals who react with alarm. They tell him Count Dracula is a vampire and when he doesn't believe them, one insists he wear a cross. When he arrives at the Castle, the Count bids him welcome. After drinking drugged wine, Renfield drops the cross and is bitten.
The setting of the film is 1920s London. Sir Roger Balfour is found shot to death in his home. Inspector Burke (Lon Chaney) of Scotland Yard is called in to investigate. The suspects are Williams (the butler), Sir James Hamlin (Henry B. Walthall) and his nephew, Arthur Hibbs (Conrad Nagel). A suicide note is found and the case is supposedly closed.
Thomas Hutter lives in the fictitious German city of Wisborg. His employer, Knock, sends Hutter to Transylvania to visit a new client named Count Orlok. Hutter entrusts his loving wife Ellen to his good friend Harding and Harding's sister Annie, before embarking on his long journey. Nearing his destination in the Carpathian mountains, Hutter stops at an inn for dinner. The locals become frightened by the mere mention of Orlok's name and discourage him from traveling to his castle at night, warning of a werewolf on the prowl. The next morning, Hutter takes a coach to a high mountain pass, but the coachmen decline to take him any further than the bridge as nightfall is approaching. A black-swathed coach appears after Hutter crosses the bridge and the coachman gestures for him to climb aboard. Hutter is welcomed at a castle by Count Orlok. When Hutter is eating dinner and accidentally cuts his thumb, Orlok tries to suck the blood out, but his repulsed guest pulls his hand away.
The film is about a woman who experiences frightening visions after visiting an insane asylum where one of the inmates claims to be Count Dracula (here following the Hungarian spelling Drakula). She has trouble determining whether the inmate's visions are real or merely nightmares.
John Schuyler (Edward José), a rich Wall Street lawyer and diplomat, is a husband and a devoted family man. He is sent to England on a diplomatic mission without his wife and daughter. On the ship he meets the "Vampire woman" (Theda Bara) who uses her charms to seduce men and leave after ruining their lives.
The film opens with a large bat flying into a medieval castle. The bat circles the room, before suddenly changing into Mephistopheles, an incarnation of the Devil. Mephistopheles produces a cauldron and an assistant, who helps him conjure a woman from the cauldron.
Very little was released publicly regarding the plot of the remake and the extent to which it would be faithful to the original. It was expected that the central focus would be on three teenagers in a family of vampires traveling Route 66 in the late 1980s.