In Muromachi period Japan, an Emishi village is attacked by a demon. The last Emishi prince, Ashitaka, kills the demon before it reaches the village, but its corruption curses his arm in the battle. The curse gives him superhuman fighting abilities, but will eventually kill him. The villagers discover that the demon was once a boar god, Nago, corrupted by an iron ball lodged in his body. The village's wise woman tells Ashitaka that he may find a cure in the western lands Nago was exiled from.
During Christmas 1955, an 11-year-old Hellboy is told a bedtime story by his adoptive father, Trevor Broom, involving an ancient war between man and magical creatures, started by man's greed. After defeat of the magical creatures' forces, the master of the goblin blacksmiths offers to build an indestructible mechanical army for the elven King Balor. Encouraged by his son Prince Nuada, Balor orders the building of this Golden Army. The humans are devastated by the army. Balor is ridden with guilt and forms a truce with the humans: Man will keep his cities and the magical creatures will keep their forests. Nuada does not agree with the truce and leaves in exile. The magical crown controlling the army is broken into three pieces, one going to the humans and the other two kept by the elves.
Kevin Lomax (Keanu Reeves), a defense attorney from Gainesville, Florida, has never lost a case. He defends a schoolteacher, Lloyd Gettys (Chris Bauer), against a charge of child molestation. Kevin believes his client is guilty, and a reporter tells him a guilty verdict is inevitable. However, through a harsh cross-examination, Kevin destroys the victim's credibility, securing a not guilty verdict.
On October 9, 2006, Kristi Rey and her husband Daniel are killed by her demon-possessed sister Katie, who then abducts Kristi's one-year-old son, Hunter. Text states that Katie and Hunter's whereabouts remained unknown.
A French priest named Moreau warns the monks of a monastery about an impending attack by the devil's forces to obtain a boy named Danny. The monastery falls under attack; Moreau tries to help the boy and his mother Nadya escape, but the distrusting mother shoots at Moreau and flees with her son. Moreau manages to distract the men chasing Danny and Nadya, but nearly dies in the process and loses them. He believes that only the Ghost Rider is capable of protecting the boy. He finds the Rider and seeks his help.
Jay Baruchel arrives in Los Angeles to visit with old friend and fellow actor Seth Rogen, who invites him to attend a housewarming party hosted by James Franco. Jay is uncomfortable being around so many people he hardly knows, so Seth accompanies him to a convenience store for cigarettes.
Robert Thorn, an American diplomat stationed in Italy, is told that his son died during birth. Unknown to his unconscious wife, Katherine, Robert adopts an orphaned newborn at the suggestion of the hospital's Catholic priest, Father Spiletto. Naming him Damien, Robert and Katherine raise the boy. Robert's career ascends over the course of the next five years. He is named Deputy Ambassador to the Court of St. James in the United Kingdom. Following the death of the previous ambassador, Robert assumes his position and settles in a large estate just outside London. However, disturbing events begin to occur, including the suicide of Damien's nanny at his birthday party.
In 1974, Ronald DeFeo, Jr. murdered his family at their house in Amityville, New York. He claimed that he was persuaded to kill them by voices he heard in the house. One year later, married couple George (Ryan Reynolds) and Kathy Lutz (Melissa George) move into the house along with the latter's three children from a previous marriage, Billy, Michael and Chelsea. The family soon begins experiencing paranormal events in the house. Chelsea (Chloë Grace Moretz) claims that she befriended a girl named Jodie, a name belonging to one of the murdered DeFeo children. One day the couple decide to go out, and they hire a babysitter to watch the 3 kids. When the babysitter, Lisa (Rachel Nichols), arrives they come to find out that she had previously been hired to babysit the DeFeos.
On October 30, 1989, Maria Rossi (Suzan Crowley) committed a triple murder during an exorcism performed on her. The Catholic Church became involved, and she has since been in a Catholic psychiatric hospital in Rome. A news story and police investigation show the three members of the clergy whom she murdered. Her daughter, Isabella, learned of the murders from her father, who died three days after telling her.
A married couple Josh (Patrick Wilson) and Renai (Rose Byrne), their sons Dalton (Ty Simpkins) and Foster (Andrew Astor), and infant daughter Cali have recently moved into a new home. One night, Dalton is drawn to the attic when he hears creaking noises and sees the door open by itself. He falls from a ladder while investigating and sees a figure in the shadows. Hearing his terrified screams, Renai and Josh rush to his aid and declare the attic "off limits" to the children. The next day, Dalton falls into an inexplicable coma.
In 1944, the Nazis build a dimensional portal off the coast of Scotland. With the help of Russian mystic Grigori Rasputin, they intend to free the Ogdru Jahad—monstrous entities imprisoned in deep space—to aid them in defeating the Allies. Rasputin knows this will be an apocalyptic event that he believes will create a paradise. He opens the portal with the aid of his disciples, Ilsa von Haupstein and Obersturmbannführer Karl Ruprecht Kroenen, member of the Thule Society and Adolf Hitler's top assassin. An Allied team is sent to destroy the portal, guided by young Trevor Bruttenholm, who is well-versed in the occult. The German team is killed and the portal is destroyed—in the process absorbing Rasputin—while Haupstein and Kroenen escape. The Allied team discovers that an infant demon with a right hand of stone came through the portal; they dub him "Hellboy" and Bruttenholm adopts him.
An injured, terrorized girl is being chased down in the woods. The men who capture her take her to some cabin's basement. They believe she is possessed by an evil entity so they have her tied to a column. Her own father is among them, and as she tries to convince him that there's nothing wrong with her, she slowly loses control and eventually it becomes clear that she is in fact possessed. In response to this her father pours flammable liquid on her, sets her on fire, then shoots her in the head.
Three thousand years ago, an Aztec warlord named Yaotl and his four generals discover a portal opening into a parallel universe which is said to have great power. Yaotl becomes immortal but at a high price, as his four generals were turned to stone. The portal releases thirteen immortal monsters that destroy his army as well as his enemies. In the present, the Teenage Mutant Ninja Turtles have grown apart. After defeating the Shredder, Master Splinter has sent Leonardo to Central America for training. Donatello works as an IT specialist, Michelangelo works as a birthday party entertainer called Cowabunga Carl and Raphael works at night as a vigilante nicknamed Nightwatcher. April O'Neil operates a company that locates and acquires relics for collectors with the help of her boyfriend, Casey Jones.
In June 2012, high school graduate Jesse Arista lives with his father, sister and grandmother in Oxnard, California. He begins to enjoy the summer with his best friend, Hector. In the apartment below lives a mysterious woman named Ana, who everyone believes to be a witch. When Ana is found murdered, Jesse and Hector spot classmate Oscar running from the scene, suggesting he was responsible. The two investigate the apartment, where they find black magic items, as well as VHS tapes and a journal of spells that can "open doorways to 'unholy lands.'"
In 1969 in Pasadena, California, a couple seeks the aid of the medium Shaun San Dena (Flor de Maria Chahua) saying their son (Shiloh Selassie) has been hearing evil spirits' voices after stealing a silver necklace from gypsies. San Dena aids the family by carrying out a seance, but they are attacked by an unseen force that pulls the boy into Hell. The medium says she will encounter the force again one day.