Autour du sultan Ali Khan (Salman Khan), un lutteur qui a des problèmes dans sa vie professionnelle et personnelle. D'un petit lutteur de l'Haryana, le Sultan atteint une renommée mondiale en gagnant les Jeux du Commonwealth de 2010 à Delhi, les Championnats du Monde de la FILA de 2011 à Istanbul, et les jeux Olympiques de Londres de 2012.
Former collegiate wrestler Scott Voss (Kevin James) is a 42-year-old bored and disillusioned biology teacher at the failing Wilkinson High School. Budget cutbacks at the school jeopardize the continuation of its music program, which would result in its teacher, Marty (Henry Winkler), being laid off. Concerned for both his colleague and his students, Scott attempts to raise the $48,000 necessary to keep the music program alive. At first, he works as a night instructor for a citizenship class. One of his students, Niko (Bas Rutten), approaches him to get some outside tutoring and Scott reluctantly agrees. When Scott arrives at Niko's apartment, he realizes that Niko was a former mixed martial arts (MMA) fighter. While watching the UFC at Niko's apartment, Scott learns that the loser of the fight receives $10,000, which gives him the idea of raising the money by fighting and losing in MMA himself. Niko begins training him in defense, and later brings him to another trainer, Mark (Mark DellaGrotte), to train for offense, after a knockout on Scott's behalf he realized he could win more and fight less. While Mark trains with Scott, Malia De La Cruz (Charice Pempengco), one of Scott's students and a band member, helps Niko study for his citizenship test by putting the information into songs. Scott then begins fighting in small MMA fights and gradually gaining higher amounts of money for the school.
Jake Tyler (Sean Faris) has recently moved from Iowa to Orlando, Florida with his mother, Margret (Leslie Hope), and younger brother, Charlie (Wyatt Smith), to support Charlie's shot at a professional tennis career. Jake was a star athlete on the football team at home, but in this new city, he is an outsider with a reputation for being a quick tempered brawler after an internet video of him starting a fight at one of his football games after a frustrated player from the opposing team taunted Jake about his father, who died in a drunk driving accident circulates around his new school.
Present day New York City: Sean MacArthur (Channing Tatum) is a street hawker. One day while selling counterfeit goods at the corner of Radio City Music Hall, a group of young men attempt to force Sean to relocate with his merchandise. These boys work for Harvey Boarden (Terrence Howard), a ticket scalper who controls the corner. Sean fights them off, but does not retain his money or products.
U.S. Marine Tommy Riordan visits his father, Paddy Conlon (Nick Nolte), a recovering alcoholic who has returned to his Catholic faith. Tommy had to run away from Paddy with his dying mother when he was just a boy due to Paddy having previously been an abusive alcoholic, and has never quite forgiven him. Paddy tries to convince him that he has changed, but to no avail. The next day, Tommy enters a gym where he beats a professional fighter named Pete "Mad Dog" Grimes (Erik Apple) unconscious in less than 30 seconds, in a fight which is filmed via a cell phone's video camera and later uploaded to the Internet, where it goes viral. Tommy learns about a winner-takes-all mixed martial arts tournament called Sparta in which the winner will receive $5,000,000. Tommy asks his father to help him train for the tournament, but only under the condition that Paddy does not try to reconcile their relationship.
The story occurs in Los Angeles, where a fight between Master Tak (Yuen Wah) and Johnny (Jerry Trimble) destroys Tak's herbal medicine store. Johnny is prevented from killing Tak when Anna (Anne Rickets) comes to save him. During his recovery he stays in Anna's camper van.
While closing his Brazilian Jiu-Jitsu studio one evening, martial arts teacher Mike Terry (Chiwetel Ejiofor) is approached by attorney Laura Black (Emily Mortimer), who is seeking the owner of the vehicle she accidentally sideswiped. Off-duty police officer Joe Collins (Max Martini), who was receiving a private lesson from Mike, sees that Laura is distressed and tries to take her coat. Startled, Laura grabs Joe's gun and fires it; shattering the studio's front window. To avoid having Laura charged with attempted murder, Mike and Joe agree to conceal the event.
After losing a fight, boxer Zack Gomes (Alex Meraz) is informed by a doctor that he has sustained a partially detached retina, and he may risk permanent blindness should he receive another hit to the head. On his way out of the hospital, he overhears the receptionist talking about MMA while viewing the website for an upcoming underground event known as "The Beatdown". Talented MMA fighter Tim Newhouse (Todd Duffee) struggles to help his family when they are in debt following the death of his father. Former high school wrestler Mike Stokes (Dean Geyer) is the new kid in college and deals with issues involving his father leaving his mother for a man. Comic book store clerk Justin Epstein (Scottie Epstein) is walking home when he is run down and stabbed by bullies. However, he is saved by Tim and his martial arts master Case Walker (Michael Jai White), who are training in a vacant lot.
Visiting the Russian Federation for a series of boxing matches, George "Iceman" Chambers is subsequently framed for possession of cocaine and sent to prison. There, he discovers a series of illegal mixed martial arts matches dominated by inmate Yuri Boyka. The prison officials arrange these fights and place large side-bets to make a personal profit, often at the expense of the fighters. He shares a cell with Steven Parker, a British junkie. Mob boss Gaga and Warden Markov tell Chambers that if he fights Boyka, he will likely get an expedited appeal and early release. Chambers initially refuses, but after spending time in demeaning physical labor in the prison's sewer system and experiencing firsthand the brutality of the guards, he reluctantly agrees. He is rescued from both forms of humiliation by a wheelchair-bound inmate named Crot. Both fighters train hard for the match, though Chambers still relies on his boxing background while Boyka prepares a series of deadly kicks, throws, and grappling combinations designed to humiliate his opponent in the ring. Prior to the fight however, Boyka's gang force Steven, who is acting as Chambers' cornerman, to spike his water with a light sedative during the fight.
The film opens at in media res where street fighting issues are raised in Mumbai. Sports chairman Peter Braganza (Kiran Kumar) expresses his desires of making street fighting a legal sport and decides to open a league called Right 2 Fight (R2F). Meanwhile, in prison, Garson "Gary" Fernandes (Jackie Shroff), a recovering alcoholic, is released from his jail term and his younger foster son Monty (Sidharth Malhotra) comes to pick him up. Monty gets a bit enraged when his father asks about his elder son David (Akshay Kumar) and takes him away to their home. David, now a physics teacher, who has a daughter suffering from a kidney disease, arranges money through street fights. This enrages his wife Jenny (Jacqueline Fernandez) as she is worried about David. Meanwhile, Gary, who misses his wife Maria (Shefali Shah), starts hallucinating about her. Gary then tries to meet David but the latter ends up throwing Monty and Gary out of his house in rage.