At its core, The Fountain is the story of a 21st-century doctor, Tom Creo (Hugh Jackman), losing his wife Izzi (Rachel Weisz) to cancer in 2005. As she is dying, Izzi begs Tom to share what time they have left together, but he is focused on his quest to find a cure for her.
Professor Calculus on (B&W) TV broadcasts an appeal to help end world hunger. He receives many letters and parcels and among them a blue orange which can grow in desert conditions (and glows in the dark) from Professor Zalamea, but no letter of explanation. That night, two thieves break into Marlinspike Hall and steal the blue orange. With no other choice, Calculus with Tintin, the Captain and Snowy go to Valencia (filmed in Burjassot, in Simat de la Valldigna at the Monastery of Santa María de la Valldigna, Gandia and Xàtiva).
In 2805, Earth is long-abandoned and covered in heaps of garbage leftover from decades of mass consumerism, facilitated by the megacorporation Buy 'n' Large (BnL). Seven hundred years earlier, BnL evacuated Earth's population in fully automated starliners, leaving behind WALL-E trash compactor robots to clean the planet for humanity's eventual return, however the plan failed and all the bots were shut off. Only one WALL-E robot remains active, and has developed sentience after so many years of life-experience. He manages to remain active by repairing himself using parts from other inactive units.
Tottington Hall's annual Giant Vegetable Competition is approaching. The winner of the competition will win the coveted Golden Carrot Award. All are eager to protect their vegetables from damage and thievery by rabbits until the contest, and Wallace and Gromit are cashing in by running a vegetable security and humane pest control business, "Anti-Pesto".