The film takes place in Minnesota, in the year of 1990. Detective Bruce Kenner (Ethan Hawke) investigates the case of John Gray (David Dencik) who admits to sexually abuse his 17-year-old daughter, Angela (Emma Watson), but has no recollection of it.
A married couple, Simon (Jason Bateman) and Robyn Callum (Rebecca Hall), relocate from Chicago to a suburban Los Angeles neighborhood after Simon finds a new job. While out shopping, they run into Gordon "Gordo" Moseley (Joel Edgerton), of Simon's former high school classmate. Soon after, Gordo begins dropping in unannounced, usually when Simon is at work, and sends many gifts including koi fish for Robyn's empty pond.
Leanne Dargon (Saoirse Ronan as an adult) is kidnapped at age 4 by Ben McKay (Jason Isaacs), who confines her to his basement and renames her Leia. She is reunited with her parents, Marcy and Glen Dargon (Cynthia Nixon and David Warshofsky) after 17 years. Suffering from Stockholm syndrome, Leia still sees Ben as her father, and sees two strangers in her biological parents. Each of the three deals with the adjustment of their reunion in different ways.
Fifty people suddenly wake up in a darkened room, arranged in two concentric circles around a strange device. Noises sound when they attempt to move or touch the others. When someone ignores the warning and leaves formation, a beam from the device kills him. As the others panic, a man attempts to calm them. In mid-sentence, he is killed by the device. Thereafter, every two minutes, a sound signals that another person will be killed. After several people die, they realize they can vote for who dies. When nobody votes, one is selected randomly.
In Depression-era North Carolina, George Pemberton struggles to maintain the future of his timber empire. His life becomes more complicated after his wife, Serena, learns that she cannot ever bear children after she suffers a miscarriage with their first child.
Still struggling over the loss of their eldest son, Caleb, to the war in Afghanistan, the Peterson family—Mr. and Mrs. Peterson and their children Luke and Anna—are unexpectedly visited by David Collins, a former soldier who claims to have been a friend of Caleb's, and is there to fulfill his promise to Caleb to help take care of the family. David is polite, warm and friendly toward the family, and Mrs. Peterson offers to let him stay as long as he needs to.
A honeymooning couple enters a pawn shop wherein the man finds his missing first wife's wedding ring, which causes him to begin searching the town for his kidnapped wife, two white supremacists plot to rob their meth supplier, and a struggling Elvis impersonator comes into town for a low-paying fairground show.
In Berlin the affluent Henriette Vogel (Birte Schnöink) holds a soiree where the poet Heinrich von Kleist attends. Heinrich approaches his close friend and cousin Marie (Sandra Hüller) and after telling her how living has become painful to him he asks her to consider dying with him in a murder-suicide pact. Marie declines.
In France, 1810, a widowed merchant (André Dussollier) is forced to sell his town house and many of his belongings after his ships are lost at sea, leaving him bankrupt. He moves to a simple house in the countryside with his six children, though the only one happy with the change is his youngest daughter, Belle (Léa Seydoux). One day news arrives that one of the merchant's ships is intact, so he and his eldest son return to town in the hopes of collecting the goods that will restore their wealth. However, the goods are seized by the local authorities, and the merchant is forced to flee into the forest when Perducas (Eduardo Noriega) threatens to harm him over his son's debts.
In 1987, Adele Wheeler (Kate Winslet) is a depressed single mom who lives in a rural home with her 13-year-old son, Henry (Gattlin Griffith). While they are clothes shopping, a bloody man approaches Henry and makes them take him home to look after him. The man is revealed to be Frank Chambers (Josh Brolin), a convict who is wanted by the local police after breaking out of jail. Through flashbacks, it is revealed that Frank is a Vietnam veteran who returned home and married his pregnant girlfriend, Mandy (Maika Monroe), who soon gave birth. A year after the baby's birth, Frank and Mandy had a fight, in which, based on his suspicions he asks if he's even the baby's father. During the fight, he pushed her against a radiator, resulting in her death. Simultaneously, through imagery, it is implied that the baby drowned. Frank was sent to jail for murder.
The story begins on the eve of the wedding of Veera Tripathi (Alia Bhatt), the daughter of a rich business tycoon. She is at a Fuel Station by the highway with her fiancé when she is abducted. The gang who kidnaps her panics when they find out that her father has links in the government. However, Mahabir Bhati (Randeep Hooda), one of her abductors, is willing to do whatever it takes to see this through. They continuously move to different cities, to avoid being tracked by police. As the days go by, Veera finds peace and a new-found freedom in her bondage to the point that she confides in him of her troubled childhood. Her fear of abduction is taken over by a sense of freedom.
Forty-year-old Christine Lucas wakes up in bed with a man she does not know, in an unfamiliar house. The man explains that he is her husband, Ben, and that she suffered brain damage from a car accident ten years earlier. Christine wakes up every morning with no memory of her life from her early twenties onwards.
In 1899, an Oxford University professor demonstrates a case of female hysteria, Lady (Eliza) Graves (Kate Beckinsale), before his class. Drugged and protesting that she is sane, the professor points out that all mental patients claim to be sane, much as all criminals claim to be innocent, as he ignores her demands that he not touch her to induce a fit for the students to observe. The professor advises his students to believe nothing they hear and only half of what they see.
Jerry is an upbeat man who works at a bathtub factory, and lives in a modified apartment above a bowling alley with his dog Bosco and his cat, Mr. Whiskers. Jerry is a man with an innocent, almost child-like demeanor, and suffers from delusions and hallucinations that manifest in the form of his pets talking to him. Bosco often represents his good intentions while Mr. Whiskers represents his more violent nature. One day, his manager compliments his hard work and chooses him to help organize an employee barbecue, and he gladly accepts the opportunity to work with his workplace crush, a British woman named Fiona. The following day he asks her out on a date. She initially agrees, though with reluctance, but then stands him up to go to a karaoke party with two other girls who work with her in the accounting department at work, Lisa and Alison. After the party, Fiona's car won't start, leading her to flag down Jerry as he drives by. Fiona offers to take him out for a late dinner to make up for standing him up on the original date, but on the way, Jerry accidentally hits a stag which crashes through his windshield. Jerry's hallucinations show the deer crying out in pain and begging Jerry to kill it so he slits the deer's throat. Fiona, terrified, runs off into the woods. Jerry pursues her and accidentally stabs her. Apologizing for his actions, Jerry kills Fiona to end her pain.