Albert Dekker plays twins, John and Paul. Paul was supposed to have died when he was 10 years old, but actually went insane and was shut up in a secret room in his parents' mansion.
The story takes place in 1903. During a train trip, psychiatrist Dr. Huntington Bailey (George Brent) meets a friendly older lady (Olive Blakeney). She tells him that she is going to visit her brother Nick and his lovely young wife Allida. Once in New York, Bailey hears that his train companion suddenly died. Shortly afterward, he meets the strange couple and becomes suspicious of Nick's treatment of his wife. Nick (Paul Lukas) keeps Allida (Hedy Lamarr), whom he is trying to pass off as crazy, a virtual prisoner in their London town house [a New York brownstone in the film], cutting off all contact with the outside world. The kindly Bailey takes it upon himself to attempt to free his new love Allida from the control of the insanely jealous Nick.
Ajay Shastri (Ajay Devgan) is an unemployed, honest graduate who dreams of joining the police force. His father, Raghuvansh Shastri (Mohan Agashe) is a highly principled and moralistic man. An ex-schoolteacher and Gandhi follower, now a social activist, Prof. Shastri expects his son to follow in his steps and believe in his ideals and values. When his father's ideals start clashing with Ajay's ideologies, a rift between father and son emerges.
Tough reporter Kenny Blake (Beaumont) falls in love with sultry Toni Kirkland (Savage) who is married to a much older man (Hicks). She seduces him to murder her husband. City editor Ward McKee (Brown), Kenny's boss and best friend, begins to pursue the tangled threads of the crime relentlessly and gradually closes the net on Kenny. In the end Tony and Kenny shoot each other. As he dies, Kenny types out his confession to the crime.
In Chicago in 1932, during Prohibition, a policeman is murdered inside a speakeasy. Frank Wiecek (Richard Conte) and another man are quickly arrested, and are later sentenced to serve 99 years' imprisonment each for the killing. Eleven years later, Wiecek's mother (Kasia Orzazewski) puts an ad in the newspaper offering a $5,000 reward for information about the true killers of the police officer.
Mastermind Dave Purvis (William Talman) is a professional criminal who devises a scheme to rob an armored car on its last pickup of the day. He recruits Benny McBride, who brings Mapes & Foster to complete the gang of thieves.
Florence Carala (Moreau) and Julien Tavernier (Ronet) are illicit lovers who plan to kill Florence's husband, Simon Carala (Wall), a wealthy industrialist who is also Julien's boss. Julien, an ex-Foreign Legion parachutist officer veteran of Indochina and Algeria, climbs up the office block on a rope, shoots Carala in his office without being seen, and arranges the room to make it look like a suicide.
Asmaa (Hend Sabry) is a woman in her 40s living with her aging father Hosni (Sayed Ragab) and teenage daughter Habiba (Fatma Adel) in Cairo, and struggling to support them with her meagre earnings from a menial job at Cairo International Airport. She is HIV-positive and requires surgery on her gallbladder, without which she will die. Doctors refuse her surgery when, on the point of entering the operating theatre, she reveals that she has AIDS.
Police Lt. Leonard Diamond is on a personal crusade to bring down sadistic gangster Mr. Brown. He's also dangerously obsessed with Brown's girlfriend, the suicidal Susan Lowell. His main objective as a detective is to uncover what happened to a woman called "Alicia" from the crime boss's past.
Walter Neff (Fred MacMurray), a successful insurance salesman, returns to his office building in downtown Los Angeles late one night. Visibly in pain, he begins dictating a confession into a Dictaphone for his friend and colleague, Barton Keyes (Edward G. Robinson), a brilliant claims adjuster. The story, told primarily in flashback, ensues.
A rich novelist, Stephen Byrne, who lives and works by a river, kills his attractive maid after she begins screaming following a drunken pass. The writer, with the help of his limping brother, loads the body into an old sack and the pair throws the body into the river. Unfortunately, the body comes back up and floats by the house days later. Despite desperate attempts by the brothers to get the body, the police end up recovering it.
The American destroyer USS Bedford (DLG-113) detects a Soviet submarine in the GIUK gap near the Greenland coast. (Specifically, they are in Greenland territorial waters at the entrance to the J.C. Jacobsen Fjord, which is due northwest from Iceland.) Although the U.S. and the U.S.S.R. are not at war, Captain Eric Finlander (Richard Widmark) harries his prey mercilessly, while civilian photojournalist Ben Munceford (Sidney Poitier) and NATO naval advisor, Commodore (and ex-World War II U-boat captain) Wolfgang Schrepke (Eric Portman), look on with mounting alarm.
Los Angeles police detective Jerry McMullen (Larry J. Blake) stops a car driven by lawyer John Morland (John Eldredge) to tell him of client Red Bailey's (Douglas Fowley) jail escape. Shortly thereafter, an armed Bailey flags down Morland's car, which police find wrecked, its driver's face beyond recognition.
In The Bronx, the Lieutenant drops his two sons off at Catholic school. After they leave the car, and before he drives to work, the Lieutenant takes a few small bumps of cocaine. His first case is a double murder. He wanders away from the scene to get some coffee, and across the street, he watches a petty thief rifling through the trunks of parked cars, which the Lieutenant ignores. He approaches a group of drug dealers, who run off as he approaches. The Lieutenant follows one dealer into an apartment building and up the stairs. The dealer waits for him in the hallway, and the Lieutenant gives him a bag of drugs from a crime scene. The Lieutenant quickly smokes some crack, and then sets aside a portion of the drugs for himself. The thief promises to give him the money he makes from selling the drugs in a few days. At an apartment, the Lieutenant gets drunk and engages in a threesome with two women. Meanwhile, a nun is raped in a church by two young hoodlums.