The film opens with Nina Eberlin (Kyra Sedgwick), the fourth in a family of six children, going to visit her divorced parents. Looking at some old photographs, she begins to tell the story of how her parents, Lainey (Anjelica Huston) and David (Sam Neill), learned that her younger brother Randall (Jamie Harrold) had autism, and how the stress that this placed on them eventually lead to the breakdown of their marriage.
In Manhattan, cockroaches are spreading the deadly "Strickler's disease" that is claiming hundreds of the city's children. Entomologist Susan Tyler (Mira Sorvino) uses genetic engineering to create what her colleague (and husband) Peter Mann (Jeremy Northam) and she call the Judas breed, a large insect (looking like a cross between a termite and a praying mantis) that releases an enzyme that kills off the disease-carrying roaches by speeding up their metabolism. The Judas breed works spectacularly and the crisis is abated. The released population was all-female and designed with a lifespan of only a few months, so that it would only last one generation.
Tim Warden, a boy with autism, has supposedly witnessed his parents' double murder. Jake Rainer, a former child psychiatrist turned therapist, is called on to probe the child's mind in order to solve the case.
Denis, un délinquant multi-récidiviste, doit choisir entre être ré-incarcéré ou être accueilli au Coral, à Aimargues (Gard), au milieu des autistes et malades psychiques. Au début, il ne pense qu'à s'enfuir, mais peu à peu, il se laisse toucher par ses nouveaux compagnons.
The film opens with a man driving a circus trailer down a silent road. He meets up with another man, John Gaveneau (Garret Dillahunt), and it is revealed that he is attempting to purchase a bengal tiger for the creation of a "Safari Ranch". Initially not believing the tiger looks dangerous or exciting enough, the seller tells him a gruesome story and claims that the tiger is evil. We then see his stepdaughter, Kelly (Briana Evigan), with her autistic brother, Tom (Charlie Tahan), whom she has taken to a special hospital in order for him to get the care he needs while she is at college. However, Kelly's check is rejected and when she phones her bank she is informed that John withdrew all the money and closed the account.
After the untimely death of a small-town church choir director (Kris Kristofferson) in Pacashau, Georgia, Vy Rose Hill (Latifah), a no-nonsense mother raising two teens alone, takes control of the choir using the traditional Gospel style that their Pastor Dale (Courtney B. Vance) approves of. However, the director's widow, G. G. Sparrow (Parton), the main benefactor to the church, believes she should have been given the position. As in previous years, the choir reaches the regional finals of the national amateur "Joyful Noise" competition, only to be disappointed when a rival choir beats them. Tough times in the town have led to budget problems that threaten to close down the choir, at the same time as the town needs the choir's inspiring music more than ever.
Jamie Benjamin is a misfit 12-year-old boy, whipping boy of his classmates, of the other kids of the city, and of the grandmothers who live in his small town. When he encounters other people, they tease and ridicule him. His only friend is a stuffed bear named Teddy, with whom he regularly holds conversations. The audience hears Teddy's voice as he talks to Jamie.
Elisabeth Shue plays the title character, Molly McKay, a 28-year-old woman with autism. She has lived in an institution from a young age following her parents' death in a car accident. When the institution must close due to budget cuts, Molly is left in the care of her non-autistic older brother, Buck McKay (Aaron Eckhart), an advertising executive and perennial bachelor. Molly, who verbalizes very little and is obsessed with lining up her shoes in neat rows, throws Buck's life into a tailspin as she runs off her nurses and barges into a meeting at Buck's agency naked.
Lieutenant Frank Barlow (Kelsey Grammer) investigates a robbery that resulted in homicide. The only witness to the crime is a nine-year-old autistic boy named Gregory White (Keegan MacIntosh). When the killers learn of Gregory's existence, they target him, and to protect the child, Barlow takes him to his rural cabin. While there, Barlow, whose own son died a year previously, bonds with Gregory.
In the year 1990, Iqbal Haroon Khan (Jackie Shroff) runs The Great Indian Circus in Chicago, which has fallen on bad times. Anderson's (Andrew Bicknell) bank — Western Bank of Chicago —, which has lent money to Iqbal Khan, decides to close down the circus when Khan is unable to repay the loan. Young Sahir (Siddharth Nigam), the little son of Iqbal Khan, pleads with Anderson not to shut down his father's circus, as he and his father would soon be able to turn the corner. But Iqbal Khan's presentation before the bankers and Sahir's pleas don't help. Iqbal Khan commits suicide in front of the heartless Anderson, leaving Sahir devastated.
In Providence, a husband and his wife die in a botched robbery; we see flickers of his last memories. His heart goes to Terry Bernard, a single father raising a girl with a rare degenerative disease. After the operation, Terry has flashes of memory from the last moments of the dead donor's life. Then, he recognizes one of the donor's killers and follows him into an alley. Within days, Terry becomes an unwilling avenger, with a police detective on his trail. Meanwhile, he begins a romance with his daughter's doctor, his moods complicated by memory flashes, the donor's deepening presence in both Terry's mind and body, and the unexplained bond among the donor's killers. Can this end well?
Victor Robinson has just moved into a country home with his family. When his son, Jesse, finds an old Edison invention and begins to play it, he hears the sounds of children laughing and playing. This is followed by Victor's autistic 12-year-old daughter, Meaghan, painting and singing; this is surrounded by strange occurrences around the house. When Victor discovers that two children were murdered in the area years before, he believes they are trying to contact him; he also believes that their neighbor is responsible for the murders.
Quinn McKenna, membre d'un commando de Rangers américains, est témoin du crash d'un vaisseau spatial lors d'une mission de sauvetage d’otages. Il est le seul survivant. Il découvre le casque et l'arme d'un Predator. Poursuivi, il décide de les envoyer par la poste à son domicile, où vit son épouse et son fils autiste, Rory. Ce dernier parvient à utiliser le masque et l'arme du Predator. Il active par ailleurs une balise qui permet à d'autres Predators de le localiser. De son côté, Quinn a été arrêté par de mystérieux mercenaires, aux ordres de Will Traeger pour le Projet Stargazer. Ce dernier fait par ailleurs appel au docteure Casey Bracket, une exo-biologiste. Elle est accueillie dans un immense complexe dans lequel est conservé un Predator. Quant à Quinn, il se retrouve dans un bus avec d'anciens soldats ayant commis de graves délits et dont la plupart souffrent de troubles psychologiques : "Nebraska" Williams, Baxley, Coyle, Lynch et Nettles.
Maggie O'Connor's (Kim Basinger) life revolves around her job as a nurse at a busy New York hospital, until one rainy night, her sister Jenna (Angela Bettis) abandons her newborn autistic daughter, Cody, at her home. Maggie takes Cody in, and she becomes the daughter she never had.
The film begins with a dim, out-of-focus corridor with machinery sounds and screams, an opening disposal chute, and the camera falling back to Earth where it is later recovered by the US Air Force. Information on-screen then reveals the recording is being used to review the footage for Project Blue Book...