Stewart Graff (Heston) is jogging near the Hollywood Sign. Back home, his wife Remy Royce-Graff (Gardner),a foul-mouthed bitter woman, starts her morning by picking a fight with him. After he has showered and is preparing to leave, Stewart finds Remy unconscious with a bottle of pills nearby. Accustomed to her periodic suicide attempts, Stewart prepares to induce vomiting when a violent tremor shakes the bedroom. Remy bolts out of bed, revealing that she was faking.
A Greek military hero named Darios (Rory Calhoun) visits his uncle Lissipu (George Rigaud) on the island of Rhodes in the year 280 BC. Rhodes has just finished constructing an enormous colossal statue of the god Apollo to guard its harbor and is planning an alliance with Phoenicia, which would be hostile to Greece.
At a ball held on the night of the 1904 presidential election, serious Louise, frivolous Helen, and stolid Grace, daughters of Silver Bow, Montana pharmacist Ned Elliott and his wife Rose, find themselves dealing with romantic prospects. Tom Knivel is about to propose to Louise when Frank Medlin, a San Francisco sports reporter, asks her to dance. Infatuated with the young woman, Frank extends his stay, and at Sunday dinner in the Elliott home he announces he and Louise plan to wed. Although her parents disapprove of the union, Louise leaves for San Francisco with Frank that night. Grace eventually marries the jilted Tom and Helen weds wealthy Sam Johnson, who promises her freedom and asks for nothing in return.
"Blackie" Norton (Clark Gable), a saloonkeeper and gambler in the notorious Barbary Coast, owns the Paradise Club on Pacific Street. He hires a promising, but impoverished, classically trained singer from Benson, Colorado named Mary Blake (Jeanette MacDonald), who becomes a star attraction at the Paradise. The piano player at the club, dubbed "The Professor" (Al Shean), can tell Mary has a professionally trained voice. Mat (Ted Healy), Blackie's good friend at the Paradise, wisely predicts that Mary is not going to stay on the "Coast".
In 1906 San Francisco, Frisco Jenny Sandoval (Ruth Chatterton), a denizen of the notorious Tenderloin district, wants to marry piano player Dan McAllister (James Murray), but her saloonkeeper father Jim (Robert Emmett O'Connor) is adamantly opposed to it. An earthquake kills both men and devastates the city. In the aftermath, Jenny gives birth to a son, whom she names Dan.
Chris Buckwell, cruel and greedy czar of San Francisco's tenderloin, is heartless in his persecution of the Chinese, though he himself is secretly a half-caste. Buckwell, eager to possess the land of Don Hernández Vásquez, sends Michael Brandon, an unscrupulous attorney, to make an offer. Brandon's nephew, Terrence, meets the grandee's beautiful daughter, Dolores, while Vásquez refuses the offer. Terry tries to save the Vásquez land grants, but when Chris causes the grandee's death, Dolores takes an oath to avenge her father. Learning that Chris is a half-caste, Dolores induces his feeble-minded dwarf brother to denounce him; he captures her and Terry, but they are saved from torture and death by the great earthquake of 1906 that kills the villain.
Wilse Dilling, a crippled brute living in the savage streets of Chinatown, receives a coded message to go to the home of his boss, Ann Cardington, known as Queen Ann, a powerful crime boss feared in the underworld. When Wilse meets with her, she sends him to the town of Fallbrook, where he is to await her instructions in dealing with a former lover of hers, a banker named Micha Hadley, who had betrayed her. Being practically wheelchair-bound has not stopped Dilling from committing a lengthy series of crimes, but to his surprise, he finds that the small town atmosphere makes him feel differently about everything. He finds a good friend in Hadley's daughter Gertrude, whom Wilse not only falls in love with but she helps him believe that he can make a fresh start. But Wilse's new-found contentment is soon shattered by a series of new developments which includes trying to stop Queen Ann's plot towards Hadley and Gertrude being killed.