The story is set in the Valley of Peace, a fictional land in ancient China inhabited by anthropomorphic animals. Po, a giant panda, is a kung fu fanatic who idolizes the Furious Five — Tigress, Monkey, Mantis, Viper, and Crane — a quintet of kung fu masters trained by the red panda Master Shifu. As he helps his goose father Mr. Ping in his noodle restaurant, Po is unable to pursue his dream of becoming a kung fu master himself.
April O'Neil (Megan Fox), a reporter for Channel 6 Eyewitness News in New York City, investigates a crime wave by criminals called the Foot Clan. At a dock at night, she sees the Foot raiding cargo containers. After an unseen vigilante attacks the thieves, April notices a symbol left behind. April's supervisor Bernadette Thompson (Whoopi Goldberg) and her coworkers are oblivious to her story. Later while covering a charity event thrown by Sacks Industries, April expresses gratitude to the company's CEO Eric Sacks (William Fichtner), who was her late father's (Paul Fitzgerald) lab partner.
Après son évasion de prison, Shredder s'allie avec le savant fou Baxter Stockman et deux hommes bêtes et costauds, Bebop et Rocksteady. Grâce à un puissant mutagène violet, ces deux derniers sont transformés en monstres ressemblant à un phacochère et un rhinocéros. De leur côté, les Tortues sont toujours aidées par April O'Neil, Vern Fenwick et un nouveau venu, le justicier hockeyeur masqué Casey Jones, pour contrecarrer ses plans. Cependant, ils doivent très vite faire face à une menace encore plus grande : Krang.
As a crime wave rises in New York City, Channel 3 news reporter April O'Neil talks about rumors of young children and teenagers being reported as the majority of the thieves, connecting it to a rumored Foot Clan, which originated in Japan. On an ordinary night, she comes across thieves stealing from a news van and is attacked. She is rescued and one of her rescuers leaves behind a sai as police arrive to collect the beaten criminals. In the storm sewers, four anthropomorphic turtles return to their underground home and meet with their master Splinter, who advises them to remain hidden from the world and work only in the shadow. Raphael admits he lost his weapon, and when the others order pizza he leaves in disguise to see a movie. After leaving the movie, he encounters Casey Jones who tries to exact justice on a pair of muggers by beating them with sporting implements. After a brief stand off between the two, Casey takes off into the city and Raphael loses his temper. Returning home, Splinter confronts Raph about his temper.
Three thousand years ago, an Aztec warlord named Yaotl and his four generals discover a portal opening into a parallel universe which is said to have great power. Yaotl becomes immortal but at a high price, as his four generals were turned to stone. The portal releases thirteen immortal monsters that destroy his army as well as his enemies. In the present, the Teenage Mutant Ninja Turtles have grown apart. After defeating the Shredder, Master Splinter has sent Leonardo to Central America for training. Donatello works as an IT specialist, Michelangelo works as a birthday party entertainer called Cowabunga Carl and Raphael works at night as a vigilante nicknamed Nightwatcher. April O'Neil operates a company that locates and acquires relics for collectors with the help of her boyfriend, Casey Jones.
A young pizza delivery boy named Keno inadvertently encounters burglars on his route and tries to stop them. Seeing him as a witness, the burglars attack Keno, who proves to be an expert martial artist, but he is soon overwhelmed before the arrival of the Ninja Turtles. They vanish after rescuing Keno, taking the pizza he was delivering and leaving money to pay for it.
Sammy, a Green sea turtle, hatches on a deserted beach and while trying to climb up a sand slope is caught by a seagull. He manages to escape along with another hatchling sea turtle caught by a seagull named Shelly. Sammy falls onto an old raft and gets carried into the open ocean, losing Shelly. Later he befriends a leatherback hatchling named Ray. The two friends grow up together.
Sammy and Ray are supervising their new offspring, when seagulls attack them and both Sammy and Ray and two of their grandchildren Ella and Ricky are captured on trawler. While Ella and Ricky are separated and sent to the seabed, Sammy and Ray are taken to an aquarium with Lulu, a lobster with dissociative identity disorder and Jimbo a bug-eyed blobfish. Escape plans are run and tried by the leading seahorse Big D. Ella and Ricky set out with Annabel and Margaret, the pink octopus mother and daughter in order to rescue their grandfathers, getting chased by a pair of barracudas when they get there. After much communication trouble, Ella and Ricky interpret from Sammy that in order to escape the aquarium several squids expel ink into the ventilation system, while all the aquarium inhabitants play dead. Before initiating the escape plan, Sammy and Ray get the tyrannical Big D out of the way. The reluctant aquarium manager opens the emergency doors allowing all sea creatures out to freedom.
In feudal Japan 1603 (Late Sengoku period) a young man is being chased by four samurai on horseback. As they go into the woods, a mysterious woman emerges from the underbrush and watches closely. However, the samurai eventually capture and take the youth, revealed to be a prince named Kenshin, with them.
A ship carrying plutonium collides with a floating atoll off the eastern coast of the Philippines, one of many incidents occurring throughout the area. As the anomalous formation approaches Japan, a team of scientists led by Naoya Kusanagi (Akira Onodera) discover orihalcum amulets and a stone slab covered in Etrurian runes on the atoll. During the investigation, the atoll suddenly quakes, destroying the slab and throwing the scientists into the ocean. One member of the team, Marine Officer Yoshinari Yonemori (Tsuyoshi Ihara), sees the eye and tusk of a giant turtle.
Three years have passed since Gamera defeated the Legion, and the world is once again plagued by the Gyaos, which have evolved into Hyper Gyaos. Mayumi Nagamine, noted ornithologist, returns to aid the Japanese government in addressing this threat. A graveyard of Gamera fossils is found at the bottom of the sea. Shadowy government agents, occultist Miss Asukura and Kurata Shinji, are meanwhile working to a different agenda, with Asukura believing Gamera to be an evil spirit.
A year has passed since the battle between Gamera and the Gyaos, and Japan has struggled to rebuild its cities in the meantime. The military has kept a cautious vigil on the nation's coast, but so far Gamera has yet to return. Suddenly, a series of bizarre incidents reveal a new threat to the land of the rising sun. On a moonlit stroll, science instructor Midori Honami watches as a huge meteor plunges into the mountain snow. The next night, two security guards are horrified as they see large insect-like creatures stealing glass bottles from a nearby warehouse. Soon after, the entire city of Sapporo is covered with strange plants and the link between these events soon becomes clear.
Gamera self-destructed to destroy several Gyaos in 1973, the tale picks up thirty three years later, when the son of one of the survivors of that incident finds an unusual egg, from which a baby turtle hatches. The boy, Toru, raises the creature, quickly realizing it as remarkable in that it hovers and breathes fire. The creature quickly outgrows the house, is relocated by Toru and his friends to maintain secrecy, and then disappears.
Un naufragé se retrouve sur une île déserte suffisamment pourvue pour l'accueillir. Il décide cependant de quitter l'endroit, mais en empêché par une grande tortue marine à la carapace rouge. Après avoir tenté de la tuer, le naufragé connaît une aventure merveilleuse et reste vivre sur l'île.
In an icy North American region, an unknown aircraft is shot down by an American fighter jet. The aircraft crashes and its cargo, a low-level atomic bomb, explodes. The resulting cataclysm awakens a giant, prehistoric monster called "Gamera", who has the appearance of a giant turtle with large tusks. Japanese scientists on an expedition (including Dr. Hidaka, Kyoko, and Aoyagi) nearby are given a "devil stone" by an Eskimo chieftain, who explains that the creature is called Gamera.