After defeating Owen Shaw and his crew and securing amnesty for their past crimes, Dominic "Dom" Toretto, Brian O'Conner, and the rest of their team have returned to the United States to live normal lives again. Brian begins to accustom himself to life as a father, while Dom tries to help Letty Ortiz regain her memories. Meanwhile, Owen's older brother, Deckard Shaw, breaks into the secure hospital the comatose Owen is being held in and swears vengeance against Dom, before breaking into Luke Hobbs' DSS office to extract profiles of Dom's crew. After revealing his identity, Shaw engages Hobbs in a fight, and escapes when he detonates a bomb that severely injures Hobbs. Dom later learns from his sister Mia that she is pregnant again and convinces her to tell Brian. However, a bomb, disguised in a package sent from Tokyo, explodes and destroys the Toretto house just seconds after Han, a member of their team, is killed by Shaw in Tokyo. Dom later visits Hobbs in a hospital, where he learns that Shaw is a rogue special forces assassin seeking to avenge his brother. Dom then travels to Tokyo to claim Han's body, where he meets and races Sean Boswell, a friend of Han's, who gives him personal items found at Han's crash site.
Tony Stark recalls a New Years Eve party in 1999 where he meets scientist Maya Hansen, the inventor of Extremis, an experimental regenerative treatment intended to allow recovery from crippling injuries. Disabled scientist Aldrich Killian offers them a place in his company Advanced Idea Mechanics, but Stark rejects the offer, humiliating Killian.
In Istanbul the MI6 agents James Bond and Eve chase a mercenary, Patrice, who has stolen a computer hard drive containing details of undercover agents placed in terrorist organisations by NATO states. Patrice wounds Bond in the shoulder and, as the two men fight atop a train, M, the head of MI6, orders Eve to fire a distant shot with a rifle at Patrice; Eve misses and inadvertently shoots Bond, allowing Patrice to escape. Bond falls into a river and goes missing, presumed to be dead.
Eight years after Harvey Dent's (Aaron Eckhart) death, the Dent Act grants the Gotham City Police Department powers which nearly eradicate organized crime. Feeling guilty for covering up Dent's crimes, Police Commissioner James Gordon (Gary Oldman) writes a resignation speech confessing the truth but decides not to use it. Batman has disappeared, and Bruce Wayne (Christian Bale) has become a recluse. Cat burglar Selina Kyle (Anne Hathaway) obtains Bruce's fingerprints from his home, kidnaps a congressman, then disappears. Selina hands Bruce's fingerprints to Phillip Stryver (Burn Gorman), an assistant to Bruce's business rival John Daggett (Ben Mendelsohn), in hope of having her criminal record erased. Stryver double-crosses Selina, but she uses the congressman's stolen phone to alert the police to their location. Gordon and the police arrive to find the congressman, and then pursue Stryver's men into the sewers while Selina flees. A masked militant named Bane (Tom Hardy) captures Gordon. Gordon escapes and is found by John Blake (Joseph Gordon-Levitt), a once-orphaned patrol officer who has deduced Batman's true identity from their similar backgrounds. Gordon promotes Blake to detective, with Blake reporting directly to him.
On a mission in Mexico, unofficially ordered by the previous M, James Bond kills two men arranging to blow up a stadium; in doing so the building they are in explodes and collapses. Bond gives chase to Marco Sciarra, who survived the blast; Sciarra boards a helicopter to escape. Bond follows and in the ensuing struggle he throws both Sciarra and the pilot out of the helicopter, stealing Sciarra's octopus ring as he does so. On his return to London Bond is indefinitely taken off field duty by the current M, who is in the midst of a power struggle with C, the head of the Joint Intelligence Service, which consists of the recently merged MI5 and MI6. C also wants to create the "Nine Eyes" intelligence co-operation agreement between nine countries, and close down the '00' section in the process.
Following their successful Rio heist, Dominic "Dom" Toretto and his professional criminal crew have fled around the world: Dom lives with Elena; his sister Mia lives with Brian O'Conner and their son, Jack; Gisele and Han live in Hong Kong; and Roman and Tej live in luxury.
In 1988, following his mother's death, a young Peter Quill is abducted from Earth by the Ravagers, a group of space pirates led by Yondu Udonta. Twenty-six years later on the planet Morag, Quill steals an orb, after which Korath, a subordinate to the fanatical Kree, Ronan, intercepts him. Although Quill escapes with the orb, Yondu discovers his theft and issues a bounty for his capture, while Ronan sends the assassin Gamora after the orb.
Two years after the Battle of New York, Steve Rogers works in Washington D.C. for the espionage agency S.H.I.E.L.D. under Director Nick Fury, while adjusting to contemporary society. Rogers and Agent Natasha Romanoff are sent with S.H.I.E.L.D.'s counter-terrorism S.T.R.I.K.E. team, led by Agent Rumlow, to free hostages aboard a S.H.I.E.L.D. vessel from Georges Batroc and his mercenaries. Mid-mission, Rogers discovers Romanoff has another agenda: to extract data from the ship's computers for Fury. Rogers returns to the Triskelion, S.H.I.E.L.D.'s headquarters, to confront Fury and is briefed about Project Insight: three Helicarriers linked to spy satellites, designed to preemptively eliminate threats. Unable to decrypt the data recovered by Romanoff, Fury becomes suspicious about Insight and asks senior S.H.I.E.L.D. official Alexander Pierce to delay the project.
In Budapest to intercept a courier working for an individual code-named "Cobalt", IMF agent Trevor Hanaway is killed by assassin Sabine Moreau. Hanaway's team leader, Jane Carter, and newly promoted field agent Benji Dunn extract Ethan Hunt and his source, Bogdan, from a Moscow prison. Ethan is recruited to lead Jane and Benji to infiltrate secret Moscow Kremlin archives and locate files identifying Cobalt. During the mission, someone broadcasts across the IMF frequency, alerting the Russians to Ethan's team. Although Benji and Jane escape, a bomb destroys the Kremlin and SVR agent Anatoly Sidorov arrests Ethan, suspecting him as a key player in the attack.
After intercepting nerve gas being sold to terrorists, Impossible Missions Force (IMF) agent Ethan Hunt (Tom Cruise) is convinced he can prove the existence of the Syndicate, an international criminal consortium that the Central Intelligence Agency (CIA) does not believe exists. Hunt is captured by the Syndicate, but escapes a torture chamber led by Syndicate member Janik "Bone Doctor" Vinter (Jens Hultén) with the help of MI6 agent and Syndicate operative Ilsa Faust (Rebecca Ferguson).
After killing Dryden, a traitorous MI6 section chief—who has been selling classified information—and the chief's contact, James Bond receives his double-0 status and is designated 007. He then travels to Madagascar in pursuit of Mollaka, a globe-trotting bombmaker-for-hire. After a parkour chase to an unnamed African embassy, Bond kills Mollaka against orders and escapes by setting off an explosion which immobilizes the embassy's security forces. Searching through Mollaka's mobile phone, Bond discovers a text message, which he traces to Alex Dimitrios, an associate of the banker and terrorist financier Le Chiffre. Aided by Mr. White, who is a representative of a terrorist organization later revealed to be Quantum, Le Chiffre is introduced to Steven Obanno, a high ranking member of the Lord's Resistance Army in Uganda, and arranges to bank several briefcases full of cash for Obanno. Le Chiffre, however, decides to invest the money into stock in a successful company called SkyFleet and then engineers a terrorist attack to sink its share prices, creating huge profits for himself.
James Bond is driving from Lake Garda to Siena, Italy, with the captured Mr. White in the boot of his car. After evading pursuers, Bond and M interrogate White regarding his organization, Quantum. M's bodyguard Craig Mitchell, a double agent, attacks M, enabling White to escape. Bond chases Mitchell and kills him. Bond and M return to London and search Mitchell's flat, discovering through tagged banknotes that Mitchell had a contact in Haiti. Bond tracks the contact, Edmund Slate, and learns that Slate is a hitman sent to kill Camille Montes at the behest of her lover, environmentalist Dominic Greene. While observing her subsequent meeting with Greene, Bond learns that Greene is helping an exiled Bolivian General, Medrano—who murdered Camille's family—to overthrow his government and become the new president in exchange for a seemingly barren piece of desert.
Genius, billionaire, and playboy Tony Stark, who has inherited the defense contractor Stark Industries from his father, is in war-torn Afghanistan with his friend and military liaison, Lieutenant Colonel James Rhodes to demonstrate the new "Jericho" missile. The convoy is ambushed and Stark is critically wounded by one of his own rocket propelled grenades. He is captured and imprisoned in a cave by the terrorist group the Ten Rings, and an electromagnet is grafted into his chest by fellow captive Yinsen to keep the shrapnel shell shards that wounded him from reaching his heart and killing him. Ten Rings leader Raza offers Stark freedom in exchange for building a Jericho missile for the group, but Tony and Yinsen agree Raza will not keep his word.
Ethan Hunt (Tom Cruise), while vacationing, is alerted by the IMF that someone has used his identity to assist Russian bio-chemical expert Dr. Vladimir Nekhorvich (Rade Serbedzija) of Biocyte Pharmaceuticals to enter the United States, only to kill him in a subsequent plane crash. Nekhorvich, an old friend of Ethan, had forewarned the IMF of his arrival, planning to deliver a new bioweapon, Chimera, and its cure, Bellerophon, both of which he was forced to develop by Biocyte, into the IMF's hands. With his death, IMF is worried that the virus is out in the open, believing that rogue IMF agent Sean Ambrose (Dougray Scott) is responsible. IMF assigns Ethan to recover it. Ethan is told that he can use two members of his team to help him, but the third person to help him must be Nyah Nordoff-Hall (Thandie Newton), a professional thief presently operating in Seville, Spain, as she will be able to get close to Ambrose, being an ex-girlfriend.