In 1938, an unlikely event unfolds as pilot Douglas Corrigan returns to the United States after his transatlantic flight, made "the wrong way" across the Atlantic. The passion to fly was there from an early age as young Douglas faced some hardships as his parents separated, leaving his mother (Dorothy Peterson) to rear two sons and a daughter.
The first half of the film concentrates on the hero's romantic, financial, and scientific struggles, starting in 1873. Most scenes are set in Boston and vicinity; a few late scenes are in London.
The family of Stephen Foster (Ameche) insists that he accept a seven-dollar-a-week shipping clerk job in Cincinnati, but he prefers to write songs. Stephen's prospective father-in-law Andrew McDowell has no faith in Stephen, who wants to write "music from the heart of the simple people of the South." The struggling composer is content to sell "Oh! Susanna" for fifteen dollars to minstrel singer E. P. Christy and allows Christy to take credit as its writer.
A family traveling through New Salem, Illinois in their wagon need groceries from Lincoln's store and the only thing of value they have is a barrel of old books including a law book, Blackstone's Commentaries. After thoroughly reading the book, Abe opts for the law after receiving encouragement from his early, ill-fated love, Ann Rutledge (Pauline Moore). Too poor to own even a horse, he arrives in Springfield on a mule and soon establishes a law practice with friend John Stuart (Edwin Maxwell). At a July 4 celebration, a man is murdered in a brawl – the accused are two brothers. Lincoln prevents the lynching of the accused at the jail by telling the angry mob he really needs these clients for his first real case. Admiring his courage, Mary Todd (Marjorie Weaver) – later to be his wife – invites Lincoln to her sister's soiree and expresses an intense interest in his future.
Pour la sixième fois, le bagnard Vidocq s'est évadé et grâce à une jeune veuve, Annette, il a pu dépister la police. Mais le frère d'Annette est assassiné et le criminel a fait retomber le meurtre sur Vidocq qui est condamné aux travaux forcés à perpétuité. Il s'évade encore, revient chez Annette et lui explique qu'il n'est pas coupable dans le meurtre de son frère. Annette, convaincu de l'innocence de Vidocq, lui donne l'occasion de refaire sa vie. Mais d'anciens compagnons de geôle font chanter Vidocq. Celui-ci s'empare de leur chef, Salembier, le livre à la police et découvre qu'il est l'assassin du frère d'Annette. Le préfet de police offre à Vidocq de devenir le chef de la Sûreté. Il accepte. Salembier, condamné à mort, s'échappe des mains de ses gardiens, tente de tuer Vidocq, mais le nouveau chef de la Sûreté abat le redoutable bandit.
Un jeune médecin de campagne, le Dr Robert Koch, est désespéré de voir une épidémie de tuberculose emporter la vie de nombreux enfants dans son secteur. Déjà un enfant sur quatre est atteint par cette maladie insidieuse, et les parents doivent veiller sur ces enfants agonisants. Depuis des années, Koch recherche fébrilement l'agent infectieux de la tuberculose.
Larry Earl est un compositeur ambitieux mais fauché; sa femme Mary persuade un directeur de théâtre de le laisser monter un spectacle avec des enfants. Mais une nouvelle loi interdit aux enfants de travailler après 10H du soir.
Nicolo Polo shows treasures from China and sends his son Marco Polo (Gary Cooper) there with his assistant (and comic relief) Binguccio (Ernest Truex). They sail from Venice, are shipwrecked, and cross the desert of Persia and the mountains of Tibet to China, to seek out Peking and the palace of China's ruler, Kublai Khan (George Barbier).
The story opens when a convicted murderer asks to make his confession on the day of his execution. The condemned man is visited by an old friend, Father Flanagan (Spencer Tracy) who runs a home for indigent men in Omaha, Nebraska. When the prison officials suggest that the condemned man owes the state a debt, Father Flanagan witnesses the condemned man's diatribe to prison officials and a reporter that describes his awful plight as a homeless and friendless boy who was a ward in state institutions. After the convicted man asks the officials to leave, Father Flanagan provides some comfort and wisdom. On the train back to Omaha, Father Flanagan is transformed in his humanitarian mission by revelations (echoed in the words) imparted by the condemned man's litany of hardships experienced as a child without friends or family as a ward of the state.
The highly fictionalised story sees 'Schani' dismissed from his job in a bank. He puts together a group of unemployed musicians who wangle a performance at Dommayer's cafe. The audience is minimal, but when two opera singers, Carla Donner and Fritz Schiller, visit whilst their carriage is being repaired, the music attracts a wider audience.