A young man, Kunle (Saheed Balogun) commits a grievous act that leaves his family members in anguish. In Lagos, Kunle hides cocaine in his mother's (Lanre Hassan) baggage before she pays a visit to his siblings, including the eldest brother Femi (Sola Fosudo) in London. His mother narrowly escapes from the British immigration officers.
Jude Keffy-Horn (Asa Butterfield) is a teenage boy who lives in Vermont with his adoptive mother, Harriet (Julianne Nicholson), and sister, Prudence (Nadia Alexander). Mixed up in the complicated world of drugs and alcohol, his best friend, Teddy (Avan Jogia), dies of a drug overdose on the last day of 1987 after Teddy, Jude and their new friend, Eliza (Hailee Steinfeld) from Manhattan spend the night out partying, leaving Jude devastated. Jude is eventually sent to Manhattan to reconnect with his father, Les (Ethan Hawke), and discovers kinship with Teddy's half-brother, Johnny (Emile Hirsch). He soon starts hanging out with Johnny's group of straight-edge friends, that have strict no-drugs, no-sex, no-meat, and no-alcohol rules, keeping Jude out of trouble for the first time in years. When he finds out that Eliza, who is also the daughter of Les' girlfriend, Di (Emily Mortimer), is pregnant with the child of deceased Teddy after an encounter on the night Teddy died, he and Johnny, along with Les, become Eliza's rock as she struggles through pregnancy so early on in life, and the three become a family of sorts, in hopes to raise the child together. Meanwhile, Di struggles with her relationship with Les, and Harriet struggles with the prospect of her growing children.
The opening scene shows Frankie being beaten by a small group of men, and the rest of the film is shown as a flashback leading up to that point. The film is split into three sections: Frankie's troubled childhood, his violent adolescence as a ska-loving skinhead who commands a small gang, and a period of change, in which Frankie tries to believe in hope and love.
Gwen Cummings (Sandra Bullock) spends her nights in a drunken haze with her boyfriend, Jasper (Dominic West). She ruins her sister (Elizabeth Perkins) Lily's wedding by showing up late and disheveled, delivering a drunken, rambling speech, and knocking over the wedding cake. Intoxicated, Gwen steals a limousine from the reception, tries to locate a cake store, and winds up losing control of the car and crashing into a house. She is given a choice between 28 days in jail or in a rehab center, and she chooses rehab.
Marty Faranan (Farrell) is a struggling writer in Los Angeles, California who dreams of finishing his screenplay, Seven Psychopaths. Marty's best friend, Billy Bickle (Rockwell), is an unemployed actor who makes a living by kidnapping dogs and collecting the owners' cash rewards for their safe return. His partner-in-crime is Hans Kieslowski (Walken), a religious man with a cancer-stricken wife, Myra. Billy helps Marty with Seven Psychopaths, suggesting he use the "Jack of Diamonds" killer, perpetrator of a recent double murder, as one of the seven "psychopaths" in his script. Marty writes a story for another psychopath, the "Quaker", who stalks his daughter's killer for decades, driving the killer to suicide and ultimately cutting his own throat to follow him to hell.
The film is a satire on the modern advertisement business. The plot mainly concerns the story of a commercial advertisement designer, Octave Parango (Jean Dujardin), who has an easy-going, highly paid job, and an active free life mainly consisting of drugs and random one-time sexual relationships. However, he starts growing weary of his job, and after having his first ever long-time relationship with fellow worker Sophie (Vahina Giocante) fail miserably, he organises a revolt against the advertisement business and his own life.
Inès Larue vient de se faire larguer avec une note d'hôtel de 12 000 euros, Pierre-Marie Archambault est un médecin alcoolique en cure de sevrage, Seb Abd Al Abbas a un bras cassé et ses vacances sont à l'eau. Trois personnages coincés dans le froid d'une station de ski, et qui auraient bien besoin d'un petit verre…
Un jeune avocat détenant des informations sur un réseau de trafiquants de faux médicaments au Nigeria fait face à un véritable dilemme en cherchant à dévoiler la vérité.