When the fearsome tiger Shere Khan (Idris Elba) threatens his life, Mowgli (Neel Sethi), a boy raised by wolves, leaves his jungle home and, guided by Bagheera the panther (Ben Kingsley) and the free-spirited bear Baloo (Bill Murray), sets out on a journey of self-discovery.
The Minister of Magic, Rufus Scrimgeour, addresses the wizarding media, stating that the Ministry would remain strong even as Lord Voldemort gains strength. Harry, Ron and Hermione prepare for a journey to find and destroy Voldemort's Horcruxes, with Harry watching Dursleys depart and Hermione wiping her parent's memories of her.
While shooting a documentary about a long-lost Indian tribe (including the legendary Joel Arkhurst), the Shirishamas, on the Amazon River, director Terri Flores (Jennifer Lopez) and members of her crew—including cameraman Danny Rich (Ice Cube), production manager Denise Kalberg (Kari Wuhrer), sound engineer Gary Dixon (Owen Wilson), visionary Warren Westridge (Jonathan Hyde), anthropologist Professor Steven Cale (Eric Stoltz), and captain of the boat Mateo (Vincent Castellanos)—come across stranded Paraguayan snake hunter Paul Serone (Jon Voight) and help him, believing he knows how to find the tribe they are searching for.
After witnessing gangster Eddie Kim brutally beat U.S. Prosecutor Daniel Hayes to death in Hawaii, Sean Jones is escorted by FBI agents Neville Flynn and John Sanders on a Boeing 747-400 to testify in a trial in Los Angeles. Despite increased security for the flight, Kim arranges for a time-release crate full of venomous snakes to be placed in the cargo hold in an attempt to bring down the plane before it reaches Los Angeles International Airport (LAX). To ensure the snakes attack the passengers without being provoked, he has one of his henchmen disguised as an airport ground employee spray the passengers' leis with a special pheromone which makes the snakes highly aggressive. The crate opens midway through the flight and the snakes make their way through the cabin. A couple having sex in the bathroom, and a man using the bathroom are the first killed. The plane's captain, Sam McKeon, investigates and fixes an electrical short, but is killed by the viper that caused it. Co-pilot Rick, unaware of the snake, believes Sam has suffered a heart attack and continues toward LAX.
Cooper (Dennis Quaid) and Leah Tilson (Sharon Stone) are living in a cramped New York City apartment with their two children, Kristen (Kristen Stewart) and Jesse (Ryan Wilson). While on a business trip overseas, Leah's boss informs her of an available promotion within the company, but only if she's willing to have an affair with him. She calls Cooper while he is dropping the kids off at school but, before she can speak to him, Jesse is hit by a car in the early morning traffic. Although he isn't hurt, Leah returns home immediately and they decide living in the city is no longer a safe option for their family.
In the West of the 1890s, a trio of outlaws, Bill Bowdre (Arthur Kennedy), Jesse Coe (Martin Landau) and Tom Fitch (Karl Malden), robs, tortures and brutally kills the white father and Indian mother of young Max Sand (Steve McQueen). Max sets out to avenge their deaths. Fitch keeps a tobacco pouch made from the breast of Max's mother, that contains a piece of beaded deerskin from her shirt. Max uses this clue to help him find the men.
An international criminal enlists Ruth Hopkins' maid and chauffeur in a scheme to kidnap her asthmatic ten-year-old son Philip for ransom. As the plot begins to unfold, Philip has just brought home a snake from a local importer, unaware that his new pet has been accidentally switched with a deadly black mamba destined for a toxicology lab. The lab reports the mix-up, and a police officer is dispatched to the Hopkins residence, only to be shot by the panicking chauffeur. The London townhouse is surrounded by police, trapping the criminals, the child, and his grandfather inside with the mamba, which is now loose in the ventilation system.
The movie begins with Dr. Carl Stoner (Martin) selling a mysterious creature in a crate to a carnival owner. It is later discovered that the creature is actually part-man/part-snake, the result of one of Stoner's bizarre experiments. College student David Blake (Benedict) is hired as an assistant by Stoner, an ophiologist. It transpires that Stoner's previous assistant had mysteriously left town without telling anyone (Stoner explains that he had gone back home to attend to a sick relative).
The story opens with a Creole woman digging up a small briefcase from the ground in the pouring rain. She then proceeds to get in her car and drives down the Louisiana road. Meanwhile, at a local burger joint, high school senior, Eden (Agnes Bruckner), is working with her best friends, Rachel (Laura Ramsey) and CeCe (Meagan Good) while the rest of her friends hang around the place. Ricky (Pawel Szajda) is aimlessly flirting with Patty (Davetta Sherwood) and Tammy (Bijou Phillips) by giving them alcohol. Eric (Jonathan Jackson) and Sean (D.J. Cotrona) talk about important matters until Ray Sawyer (Rick Cramer) pulls up in his tow truck. Everyone stares and whisper rumors about him while Ray picks his order up. Ray is Sean's biological father. After he leaves, Rachel says how much he scares her, while Tammy flashes Ray while he eats in his truck. After work, Eden begins to bike home alone, but Eric catches up to her to talk to her about going to college in New York. While they were talking, Ray drives up and asks if Eden's alright. When he's sure, he begins to leave when another car, carrying the Creole woman from the beginning of the film - who is CeCe's grandmother - passes by. CeCe's grandmother's car falls halfway off the bridge. Ray gets out of the truck and helps Eric save the woman. Ray saves her, but the woman begs Ray to get the suitcase. As Ray reaches into her car to get it, the suitcase lid flies open as the car falls off of the bridge and begins to sink into the water below. Upon opening, the suitcase releases several horrifying snakes. As the car sinks into the bayou the snakes attack Ray. The ambulance arrives to find Ray dead along with CeCe's grandmother. CeCe arrives shaken up over the tragedy, and takes a charm that was on her grandmother's corpse. CeCe then surprises Eden and Eric by questioning them about the condition of Ray's body.
A team of researchers funded by a Manhattan pharmaceutical firm – Jack Byron, Gordon Mitchell, Sam Rogers, Gail Stern, Cole Burris, and Ben Douglas – leave for a jungle in Borneo to search for a "blood orchid", a flower they believe can be used as a type of fountain of youth. Though their guide Bill Johnson has misgivings about which path to take, Jack bribes him to take an unsafe path. The team goes over a waterfall and has to wade through the river. A giant anaconda emerges from the water and swallows Ben whole, but the rest of the team escapes the river. Bill assures them that it was the largest snake he has ever seen and that it should take weeks for it to grow hungry again; however, most of the team demands that the expedition be called off. They travel to Bill's friend, John Livingston, who lives on the river to see if Johnson can borrow his boat; however, they find Livingston dead and his boat crashed.
In an Indian village, Buldeo, an elderly storyteller, is paid by a visiting British memsahib to tell a story of his youth. He speaks of the animals of the jungle, and of the ever-present threats to human life posed by the jungle itself. He then recalls his early life:
Xu-Xian, a young boy, once owned a pet snake in West Lake until his parents forced him to give her up. Years pass and during a violent storm, the snake magically transforms into the beautiful princess Bai-Niang. Bai-Niang finds Xu-Xian, but the lovers are separated by a local monk, Fa-Hai, who believes that Bai-Niang is an evil spirit. Xu-Xian's two panda pets, Panda and Mimi, try to find Xu-Xian. In the end, Bai-Niang gives up her magical powers and remains in human form to prove that her love for Xu-Xian is genuine.
The film begins following the life of Neang Nhi, a Cambodian woman. Nhi is married to her husband Minom. Nhi and Minom have a young daughter. One day, Minom leaves town for work, leaving his daughter and wife at home. He tells their daughter that he will return home soon.
Jason Kincaid (Oliver Reed) has a massive serpent captured in a remote island. He brought it to the US because it killed his brother, and he now shares some kind of psychic link with it. He enlists the help of psychologist Tom Brazilian (Peter Fonda) to study the animal and the mental connection, but they do not count on a group of snake worshiping Satanists to complicate matters by accidentally setting the beast free.