Père adoptif de Gamora et Nébula, Thanos a commencé à recueillir les six Pierres d'Infinité : la Pierre du Pouvoir, la Pierre de l'Espace, la Pierre de Réalité, la Pierre de l'Âme, la Pierre du Temps et la Pierre de l'Esprit. Son objectif est de réunir ces six gemmes sur un gantelet doré, forgé par le nain Eitri sur Nidavellir, afin d'utiliser leur immense puissance pour détruire la moitié de la population de l'Univers et rétablir ainsi un certain équilibre. Dans sa quête le menant sur diverses planètes, la Terre, Knowhere et Vormir, Thanos est aidé par ses enfants adoptifs : Ebony Maw , Cull Obsidian , Corvus Glaive et Proxima Midnight . Face à cette nouvelle menace qui concerne l'Univers entier, le groupe de super-héros des Avengers, divisé depuis 2 ans, doit se reformer, et s'associer au Docteur Strange, aux Gardiens de la Galaxie et au peuple du Wakanda.
Le Soldat de l'Hiver (alias Bucky Barnes) a autrefois été reconditionné dans une base militaire soviétique sibérienne et hypnotisé à l'aide de certains mots. Quiconque prononce ces mots en russe plonge le Soldat de l'Hiver en transe et peut lui donner n'importe quel ordre sans qu'il puisse désobéir. C'est ainsi qu'en 1991, le Soldat de l'Hiver a provoqué l'arrêt brutal d'une voiture pour s'emparer dans son coffre d'une valise avec un étrange contenu.
Dévasté par la disparition d'Iron Man, son mentor, Peter Parker a pour projet de laisser son costume de super-héros derrière lui pendant quelques semaines afin de partir en vacances en Europe avec ses camarades lycéens, mais cette escapade est rapidement compromise quand il accepte à contrecœur d'aider Nick Fury à découvrir le mystère de plusieurs attaques de créatures, qui ravagent le continent.
Gandalf leads Aragorn, Legolas, Gimli, and King Théoden to Isengard where they reunite with Merry and Pippin, who helped the Ents destroy Saruman’s forces. With Saruman himself defeated, Gandalf retrieves Saruman’s palantír which is viewed by a curious Pippin, allowing Sauron to attack the Hobbit’s mind. Gandalf deduces Sauron will attack Gondor’s capital Minas Tirith, riding there with Pippin. They meet Lord Denethor, steward of Gondor, and Boromir’s father. Pippin declares his service to Denethor after Boromir died protecting him.
Peter Parker plans to propose to Mary Jane Watson, who has just made her Broadway musical debut. A meteorite crashes near the two in Central Park, and an extraterrestrial symbiote attaches itself to Peter's moped. While fleeing police, escaped prisoner Flint Marko falls into a particle accelerator that fuses his DNA with surrounding sand, allowing him to shapeshift at will as the Sandman. Peter's best friend, Harry Osborn, who blames him for his father's death, attacks Peter using weapons based on his father's Green Goblin technology. Harry injures his head and suffers partial amnesia, forgetting that Peter is Spider-Man and his desire for revenge. During a festival honouring Spider-Man, Marko robs an armored car. NYPD Captain George Stacy tells Peter and Aunt May that Marko was Uncle Ben's killer, and Dennis Carradine was only an accomplice. While a vengeful Peter sleeps, the symbiote bonds with him. Peter wakes up hanging from a skyscraper. His costume becomes black and his powers increase, but the symbiote brings out Peter's dark side. Wearing the new suit, Spider-Man locates Marko and battles him in a subway tunnel, reducing him to mud using water.
À la suite de sa participation à l'affrontement entre Iron Man et Captain America, Peter Parker, un jeune lycéen fréquentant le lycée de Midtown, continue à se servir de ses pouvoirs sous le masque de Spider-Man pour lutter contre la criminalité qui ronge la ville de New York, tout en essayant de trouver un équilibre entre sa vie de lycéen, son amour secret pour Liz, son ami Ned Leeds, et sa carrière de super-héros masqué. Mais avec la venue d'un nouveau super-vilain nommé le Vautour équipé d'un exosquelette créé à partir de technologie Chitauri (récupérée après la bataille de New York), Peter devra faire ses preuves en affrontant ce dernier pour prouver à Tony Stark qu'il peut être un atout pour l'équipe des Avengers.
Harry Potter spends the summer at the Dursleys' house without receiving letters from his Hogwarts friends. He is sent to his room by The Dursleys to avoid embarassing them in front of Uncle Vernon's friends, who are coming over as guests.
High-school senior Peter Parker visits a genetics laboratory with his friend Harry Osborn and love interest, Mary Jane Watson for a school field trip. There, Peter is bitten on the hand by a genetically engineered "super spider". Shortly after arriving home to his Aunt May and Uncle Ben, he goes unconscious. Meanwhile, Harry's father, scientist Norman Osborn, owner of Oscorp, is attempting to preserve his company's critically important military contract. He experiments on himself with a new but unstable performance-enhancing chemical vapor that increases his speed, strength, and stamina. However, it also drives him insane and he kills his assistant, Mendel Stromm. The next morning, Peter finds that his previously impaired vision has improved and his body has metamorphosized into a more muscular physique. At school, he finds that his body can produce webs and his quickened reflexes let him avoid injury during a confrontation with bully Flash Thompson. Peter discovers he has developed superhuman speed, strength, the ability to stick to surfaces, and a heightened ability to sense danger.
Peter Parker struggles to balance his crime-fighting duties as Spider-Man with the demands of his normal life. He loses a job, faces financial difficulties, and struggles to attend his physics lectures at Columbia University on time. Estranged from both love interest Mary Jane Watson and best friend Harry Osborn, who intends to seek revenge on Spider-Man for his father Norman's death, Peter additionally discovers his Aunt May is facing foreclosure.
A young Peter Parker discovers his father Richard Parker's study has been burgled. Gathering up hidden documents, Peter's parents take him to the home of his Aunt May and Uncle Ben, then mysteriously depart.
OsCorp scientist Richard Parker records a video message to explain his disappearance. Later, he and his wife, Mary, are aboard a private jet hijacked by a man sent to assassinate Richard. The plane crashes, killing both Richard and Mary, after he uploads the video.
The night before their flight to Paris for a Christmas holiday, the McCallister family gather at the Winnetka, Illinois home of Peter (John Heard) and Kate (Catherine O'Hara) McCallister. Their 8-year-old son, Kevin (Macaulay Culkin), is ridiculed by his siblings and cousins. After a fight with his older brother, Buzz (Devin Ratray), Kevin is sent to the third floor of the house, where he wishes that his family would disappear. During the night, a power outage resets the alarm clocks and causes the family to oversleep. In the confusion and rush to reach their flight on time, Kevin is left behind and the family is unaware until they are already airborne. Once in Paris, Peter and Kate try to book a flight home, but all the flights are booked for the next two days. The clerks put Kate on standby for any possible seat opening. The rest of the family goes to Peter's brother's home in Paris, and Kevin's siblings and cousins are crushed by empathy for their abuse toward Kevin.
One spring, on a farm in Somerset County, Maine, Fern Arable (Dakota Fanning) finds her father about to kill the runt of a litter of newborn pigs. She successfully begs him to spare its life. He gives it to her, who names him Wilbur and raises him as her pet. To her regret, when he grows into an adult pig, she is forced to take him to the Zuckerman farm, where he is to be prepared as dinner in due time.
Entomologist Dr. James Atherton (Julian Sands) searches the Amazon rainforest with the hope of discovering new species of insects and arachnids. Descending into an enormous sinkhole, his team sets up collectors on the ground below a large tree, then blow smoke up into the canopy of the tree. A large number of bugs fall into the collector, including a very aggressive new species of spider. The spider is captured and chloroformed for research; and is later revealed to be lacking sex organs, thus making it a drone, or soldier, highly unusual in an arachnid species. A nature photographer, Jerry Manley (Mark L. Taylor), who has been suffering a fever while traveling with the team, unknowingly has a fertile (non-drone) male spider of the same species jump into his backpack, that night sneaking into his sleeping bag and biting him. Manley has a massive seizure from the venom and dies. The remainder of the scientists takes his body back to the United States, blaming Manley's death on the preexisting fever. The spider crawls into the box and is sealed in with the corpse.