In 1961, the Ark, a Cybertronian spacecraft carrying an invention capable of ending the war between the Autobots and Decepticons, lands on the far side of the Earth's Moon. The crash is detected on Earth by NASA, and President John F. Kennedy authorizes a mission to put a man on the Moon as a cover for investigating the craft. In 1969, the crew of Apollo 11 lands on the Moon to explore the craft.
Gru, a supervillain, has his pride injured when an unknown supervillain steals the Great Pyramid of Giza, an action that is described by his colleague Dr. Nefario as "making all other villains look lame." Gru decides to do better, with the assistance of Dr. Nefario, by shrinking and stealing the Moon, an idea based on his childhood dream of being an astronaut, which was always disparaged by his mother Marlena. The plan is expensive and Gru seeks a loan from the Bank of Evil, where the president Mr. Perkins is impressed by the plan, but will only provide the money if Gru can obtain the necessary shrink ray first.
On July 20, 1969, astronaut Jim Lovell hosts a party, where guests watch on television as Neil Armstrong takes his first steps on the Moon during Apollo 11. After the party, Lovell, who had orbited the Moon on Apollo 8, tells his wife Marilyn that he intends to walk on the Moon's surface.
Austin Powers is enjoying his honeymoon with his wife, the former Vanessa Kensington. She turns out to be one of Dr. Evil's fembots, who attempts to kill Austin, then self-destructs. Austin grieves briefly, then proceeds to the hotel lobby nude and celebrates being single again.
Les parents de Katherine Coleman apprennent que leur fille possède un don pour les sciences, qu'elle doit parfaire en fréquentant une école pour Noirs (les écoles étant séparées selon la couleur de peau à cette époque) car elle est dotée d'aptitudes intellectuelles supérieures. En 1962, devenue mathématicienne, Katherine Coleman (désormais Goble) travaille au sein d'un groupe de calculatrices humaines, sur le campus ouest du Centre de recherche Langley à Hampton en Virginie aux États-Unis, avec deux amies et collègues : l'aspirante ingénieure Mary Jackson et la superviseure d'équipe Dorothy Vaughan. À la suite du lancement réussi de Spoutnik 1, Al Harrison, directeur du Space Task Group, exige encore plus d'efforts de la part des employés sous sa supervision de crainte que les Soviétiques ne mettent en orbite une bombe H pouvant exploser au-dessus du sol américain. Goble est envoyée dans son groupe pour vérifier les calculs, devenant la première Afro-Américaine à participer à ce groupe de recherche. Au début, elle est ignorée de ses collègues blancs et doit travailler à partir de données partiellement masquées (Goble n'ayant pas le niveau d'habilitation nécessaire) sous les ordres de Paul Stafford, un homme croyant en sa supériorité intellectuelle et refusant de reconnaître le travail de Katherine.
Prior to the destruction of Krypton, the criminals General Zod (Terence Stamp), Ursa (Sarah Douglas) and Non (Jack O'Halloran) are sentenced to banishment into the Phantom Zone for insurrection and murder, amongst other crimes.
Set in the future, the film's prologue depicts Jim Hawkins as a five-year-old (voiced by Austin Majors) reading a storybook in bed. Jim is enchanted by stories of the legendary pirate Captain Flint and his ability to appear from nowhere, raid passing ships, and disappear in order to hide the loot on the mysterious "Treasure Planet". Twelve years later, Jim (Joseph Gordon-Levitt) has grown into an aloof and alienated teenager. He is shown begrudgingly helping his mother Sarah (Laurie Metcalf) run an inn and deriving amusement from "solar surfing" (a hybrid of skysurfing and windsurfing atop a board attached to a solar sail-powered rocket), a pastime that frequently gets him in trouble.
In an African desert millions of years ago, a tribe of man-apes is driven from their water hole by a rival tribe. They wake to find a featureless black monolith has appeared before them. One man-ape realizes how to use a bone as a tool and weapon; the tribe kills the leader of their rivals and reclaims the water hole.
The narrator explains that in 1957, the Soviet Union launched Earth's first satellite Sputnik 1 into orbit. Four years later in 1961, when NASA was putting a monkey named Enos aboard Mercury Atlas 5, astronaut Yuri Gagarin became the first man on Earth to go to space. The Soviets were beating the Americans in every milestone off the planet. Feeling the sense of urgency to overtake the Soviets in the space race, U.S. President John F. Kennedy made a huge statement toward a joint session of Congress on May 25, 1961, stating that before the decade is out, he plans to launch the man to the Moon and return him safely to the Earth.
After the mysterious failure of the Discovery One mission to Jupiter in 2001, which resulted in the deaths of four astronauts and the disappearance of David Bowman, the fiasco was blamed on Dr. Heywood Floyd, who resigned his position as head of the National Council for Astronautics. While an international dispute causes tensions between the United States and the Soviet Union, both nations prepare space missions to determine what happened to the Discovery. Although the Soviet ship, the Leonov, will be ready before the American spacecraft Discovery Two, the Soviets need American astronauts to help board the Discovery and investigate the malfunction of the ship's sentient computer, HAL 9000, which caused the disaster. The US government agrees to a joint mission when it is determined that Discovery will crash into Jupiter's moon Io before Discovery Two is ready. Floyd, along with Discovery designer Walter Curnow and HAL 9000's creator Dr. Chandra, joins the Soviet mission.
In the near future, the Moon has been colonized and supports a station on its surface. A lunar shuttle known as Mayflower One is being rushed to launch from Houston. The head of the ground crew, The Sarge (Chuck Connors), does not like what is occurring, but he defers to the airline's management.
In December 1974, the crew of the cancelled Apollo 18 mission is informed that it will now proceed as a top secret Department of Defense (DoD) mission disguised as a satellite launch. Commander Nathan Walker, Lieutenant Colonel John Grey, and Captain Ben Anderson are launched toward the Moon to place detectors to alert the United States of any impending ICBM attacks from the USSR.
A bamboo cutter named Sanuki no Miyatsuko discovers a miniature girl inside a glowing bamboo shoot. Believing her to be a divine presence, Miyatsuko and his wife decide to raise her as their own, calling her "Princess". The girl grows rapidly and conspicuously, marveling her parents and earning her the nickname "Takenoko" (Little Bamboo) from the other children in the village. Sutemaru, the oldest among Kaguya's friends, develops a particularly close relationship with her.
Superman saves a spaceship of cosmonauts whose ship was thrown off course by debris, then visits his home-town of Smallville as Clark. Now that his adoptive parents have died, Clark has inherited their now-unattended farm. In an empty barn, he uncovers the capsule that brought him to Earth, and removes a luminescent green Kryptonian energy module. A recording left by his mother Lara (voiced by Susannah York) states that its power can be used only once. Unwilling to sell the farm to a mall developer, Superman returns to Metropolis.