Ten years after the worldwide pandemic of the deadly ALZ-113 virus (known as the Simian Flu), human civilization is completely destroyed following martial law, civil unrest and the economic collapse of every country in the world. Over 90% of the human population has died in the pandemic, while apes with genetically enhanced intelligence have started to build a civilization of their own.
Deux ans après avoir affronté les humains et Koba, César et les singes vivent reculés dans une forêt. Leur avant-poste est alors attaqué par une unité militaire pratiquement annihilée dans l'assaut et qui subit une défaite totale, rapportée par radio à leur commandant le colonel McCullough. Selon les dires d'un survivant fait prisonnier et présenté à César, cet homme sanguinaire cherche à tout prix à retrouver César pour installer la domination des hommes sur les primates : bien que ça ne fasse pas l'unanimité, César choisit d'épargner les soldats survivants et de les lui renvoyer avec un message de laisser tomber afin de clarifier les circonstances ayant amené cette situation et prévenir une montée vaine des conflits. Plus tard alors qu'ils s'occupent de leurs morts et blessés, César vient accueillir son fils aîné Yeux-Bleus et Rocket, qui reviennent d'une expédition prolongée et ont apparemment enfin trouvé la terre promise des singes, à des mois de marche de là. Le soir même, après des discussions houleuses sur la suite des événements et la crainte exprimée par Winter, un gorille albinos, la décision est prise de s'y rendre. Mais après l'échec de ses soldats, le colonel McCullough se déplace en personne avec un commando dans le refuge de César afin de le tuer. Il tue le fils aîné de César par méprise ainsi que sa compagne, Cornelia, épargnant sans le savoir leur enfant cadet, Cornelius qui s'était caché. César qui arrive juste avant son départ et constate leur mort, tente de se venger pour son acte mais échoue de peu. Tandis que la colonie a débuté son trajet vers leur futur foyer, César confie alors Cornelius à Lake, la compagne de feu son fils aîné, puis quitte les siens à leur grande surprise pour se lancer seul à la poursuite de McCullough, assoiffé de vengeance. Il est toutefois vite rattrapé et épaulé par ses plus proches amis l’orang-outan Maurice, le chimpanzé Rocket (dont le fils Ash, meilleur ami de Yeux-Bleus, fut également tué, par Koba en son temps) et le gorille Luca.
Will Rodman, a scientist at the biotechnology company Gen-Sys, is testing viral-based drug ALZ-112 on chimpanzees to find a cure for brain ailments such as Alzheimer's disease. The drug is given to a chimpanzee, Bright Eyes, greatly increasing her intelligence. However, when Will is presenting 112 to his boss and uses Bright Eyes as an example, she is forced from her cage, goes on a rampage, and is killed. Will's boss Steven Jacobs terminates the project and orders chimp handler Robert Franklin to euthanize the chimps. After doing as ordered, Franklin discovers that Bright Eyes had recently given birth and understands the reason why she was disturbed. He convinces Will to save the baby chimp's life by taking him home temporarily. Will's father Charles, who is suffering from Alzheimer's, names the chimp "Caesar", in reference to William Shakespeare's play Julius Caesar, from which he can, despite his deteriorating mental condition, cite long passages from memory. Will learns that Caesar has inherited his mother's high intelligence (the 112 virus passing to him in utero) and decides to raise him, working from home and observing his behavior in hopes that he can get the project restarted. Three years later, Will introduces Caesar to the redwood forest at Muir Woods National Monument. Meanwhile, with Charles' condition rapidly deteriorating, Will treats him with ALZ-112 and he is restored to better-than-original cognitive ability.
En 2020, dans un monde post-apocalyptique : les rares survivants vivent sous la menace de créatures très sensibles aux sons, et doivent ainsi demeurer dans le silence. Une famille du Midwest va devoir apprendre à lutter pour survivre, alors que la mère est sur le point d'accoucher.
Jerry Maguire (Tom Cruise) is a glossy 35-year-old sports agent working for Sports Management International (SMI). After having a life-altering epiphany about his role as a sports agent, he writes a mission statement about perceived dishonesty in the sports management business and his desire to work with fewer clients so as to produce better quality. In turn, Management decides to send Bob Sugar (Jay Mohr), Jerry's protégé, to fire him. Jerry and Sugar call all of Jerry's clients to try convincing them not to hire the services of the other. Sugar secures most of Jerry's previous clients. Jerry speaks to Arizona Cardinals wide receiver Rod Tidwell (Cuba Gooding, Jr.), one of his clients who is disgruntled with his contract. Rod tests Jerry's resolve through a very long telephone conversation while Sugar is able to convince the rest of Jerry's clients to stick with SMI instead. Leaving the office, Jerry announces that he will start his own agency and asks if anyone is willing to join him, to which only 26-year-old single mother Dorothy Boyd (Renée Zellweger) agrees. Meanwhile, Frank "Cush" Cushman (Jerry O'Connell), a superstar quarterback prospect who expects to be the number one pick in the NFL Draft, also stays with Jerry after he makes a visit to the Cushman home. However, Sugar is able to convince Cushman and his father at the last minute to sign with SMI over Jerry. Cushman's father implies they decided to sign with Sugar over Jerry when they saw Jerry attending to Tidwell; an African-American player, versus his son (a white player).
Baby est chauffeur pour un gang de braqueurs à Atlanta. Enfant, il a survécu un accident de voiture au cours duquel ses parents sont tués, mais qui lui cause des acouphènes qu'il atténue avec la musique. Il travaille dorénavant pour Doc, le chef du gang, afin de rembourser une dette en compensation d'avoir volé une voiture. Entre deux jobs, il fait des remixes des conversations enregistrées et prend soin de son père adoptif atteint de surdité, Joseph. Un jour, il fait la rencontre de la jeune et jolie Debora, serveuse d'un diner, avec lequel il sympathise avant de commencer à sortir ensemble. Lors d'un nouveau « boulot » au cours duquel un témoin armé l'a poursuivi ainsi que la police avec le gang, avant de parvenir à s'échapper, Baby quitte le monde criminel après avoir payé sa dette auprès de Doc et devient livreur de pizzas. Alors qu'il a invité Debora au restaurant, Baby, pensant fuir un monde qui ne lui ressemble pas, a la désagréable surprise de voir Doc, qui interrompt leur dîner. Ce dernier contraint le jeune homme à participer à un autre coup en dévalisant un bureau de poste, sous peine de s'en prendre à Debora et Joseph.
Sans famille, Elisa Esposito (Sally Hawkins) a été trouvée, enfant, dans une rivière. Elle porte au cou des cicatrices semblant témoigner de violences exercées sur son larynx, qui expliqueraient qu'elle soit muette. Elle vit dans une grande solitude, tout comme son voisin de palier Giles (Richard Jenkins), un vieil homosexuel, illustrateur publicitaire sans emploi.
Alex Shaw is on a motorcycle chase after a vehicle with stolen goods. He eventually catches the driver of the vehicle, but his girlfriend Annie runs into him during her driving test. She finds out that Alex is on the SWAT team after he lied and told her he was a beach cop. As an apology, Alex surprises her with a Caribbean cruise on Seabourn Legend.
Charles Travis (Bruce Campbell) and Karen Ross (Laura Linney) are testing a communications laser in a remote part of the Congo near a dormant volcano when Charles' friend Jeffrey (Taylor Nichols) discovers an ancient lost city's ruins. When Jeffrey and Charles go to explore it, they are both mysteriously killed. While Karen waits at headquarters, she activates a video feed and sees a destroyed camp with several dead bodies. The camera is then suddenly knocked over by a strange creature, ending the transmission. TraviCom's CEO and Charles' father R.B. Travis (Joe Don Baker) reveals they were really exploring the Congo to find a rare blue diamond that's only found at the volcanic site.
In 1965, Glenn Holland (Richard Dreyfuss) is a professional musician and composer who has been relatively successful in the exhausting life of a musician. However, in an attempt to enjoy more free time with his young wife, Iris (Glenne Headly), and to enable him to compose a piece of orchestral music, the 30-year-old Holland accepts a high school teaching position.
A Boston couple, Gail (Meryl Streep) and Tom (David Strathairn), are having marital problems, due to his inability to spend time with his family because of his work as an architect. She, a water rafting expert, decides to take their son, Roarke (Joseph Mazzello), on a holiday rafting trip down the Salmon River in Idaho, along with their dog, Maggie. Their daughter, Willa (Stephanie Sawyer), accompanies them to Gail's parents' house in Idaho. At the last minute, just when they are about to leave for the almost week-long trip, Tom joins them. As they are setting off, they meet a couple of other rafters, Wade (Kevin Bacon) and Terry (John C. Reilly), who appear to be friendly. Thus they leave for the trip, leaving Willa behind to be taken care of by her grandparents.
Set in the fictional town of Thayer, Massachusetts, the story focuses on Meredith Morton (Sarah Jessica Parker), a successful Manhattan executive whose uptight, conservative demeanor is a sharp contrast to that of her boyfriend Everett Stone (Dermot Mulroney) and his liberal and rambunctious family.
Kate and John Coleman (Vera Farmiga and Peter Sarsgaard) are experiencing strains in their marriage after their third child was stillborn. The loss is particularly hard on Kate, who is also recovering from alcoholism. The couple decides to adopt a 9-year-old Russian girl, Esther (Isabelle Fuhrman) from a local orphanage. While Kate's and John's deaf daughter Max (Aryana Engineer) embraces Esther immediately, their son Daniel (Jimmy Bennett) is less welcoming. Kate suspects that there might be problems in Esther's background when Esther's knowledge of sex extends beyond her age. Her suspicions deepen when Esther seriously injures another girl who had bullied her.
In 1898, Daniel Plainview, a prospector in New Mexico, mines a potentially precious ore vein from a pit mine hole. In the process of dynamiting the lode, he falls from a broken rung of the tunnel ladder and breaks his leg. He saves a silver sample, climbs out of the mine, and drags himself to the nearest assay office to record his and gets a Silver and Gold certificate claim. In 1902, he discovers oil near Los Angeles, California and establishes a small drilling company. Following the death of a worker in an accident, Daniel adopts the man's orphaned son. The boy, named H. W., becomes his nominal "business partner", allowing Daniel to paint himself to potential investors as "a family man".
When Cole's Department Store's Santa Claus gets drunk before taking part in the Thanksgiving parade, Dorey Walker (Elizabeth Perkins), Cole's director of special events, fires him and must find a replacement immediately. She spots an old man (Richard Attenborough) berating the inebriated Santa, and begs him to take over. He introduces himself as Kris Kringle. Kris does so well during the parade that he is immediately hired to be Cole's main Santa for the holiday period. All the children in New York begin to believe that he is the real Santa, with the exception of Dorey's six-year-old daughter Susan (Mara Wilson). Dorey's boyfriend, Bryan Bedford (Dylan McDermott), does his best to convince Susan to believe. While being babysat one night by Kris, Susan shares with him her Christmas wish, she would like a dad, a house (used every year for the Cole's catalogue photoshoot) and a baby brother. Kris asks if she would begin to believe in Santa if she got all those things. Susan agrees that she would.