Frenchmen Mario and Jo, Dutchman Bimba and Italian Luigi are stuck in the isolated Southern Mexican town of Las Piedras. Surrounded by desert, the town is linked to the outside world only by a small airport, but the airfare is beyond the means of the men. There is little opportunity for employment aside from the American corporation that dominates the town, Southern Oil Company (SOC), which operates the nearby oil fields and owns a walled compound within the town. SOC is suspected of unethical practices such as exploiting local workers and taking the law into its own hands, but the townspeople's dependence upon it is such that they suffer in silence.
The film is presented in a nonlinear narrative, cutting back and forth between McCandless's time spent in Alaskan wilderness and his two-year travels leading up to his journey to Alaska. The plot summary here is told in a more chronological order.
The film opens with a prologue that consists of four segments described by critics as "vignettes". They show the principal characters in different parts of the world and provide their backstories.
David Mann (Dennis Weaver) is a middle-aged Los Angeles electronics salesman driving his red 1971 Plymouth Valiant sedan on a business trip. On a two-lane highway in the California desert, he encounters a grimy and rusty 1955 Peterbilt 281 tanker truck, traveling slower than the speed limit and expelling thick plumes of sooty diesel exhaust. Mann passes the unsightly truck, which promptly roars past him and then slows down again. Mann is unmoved, passing the truck a second time, and is startled when it suddenly issues a long air horn blast.
John W. "Jack" Burns (Kirk Douglas) works as a roaming ranch hand much as the cowboys of the old West did, refusing to join modern society. He rejects much of modern technology, not even carrying any identification such as a driver's license or draft card. He can't provide an address because he just sleeps wherever he finds a place.
Hank (Richard Locke), a trucker, turns out new hire Joe on a long haul to the West Coast. The men masturbate together while on the road and participate in an all-male orgy at a truckers' bunkhouse in Los Angeles. The film features several trucking related double-entendres such as "wide load", "heavy load" and "men at work".
In a small town in Upstate New York named "Sam Dent", a school bus skids into a lake, killing 14 children. Their grieving parents are approached by a lawyer, Mitchell Stephens (Ian Holm), who is haunted by his dysfunctional relationship with his drug-addict daughter. Stephens persuades the reluctant parents to file a class action lawsuit against the state, school district, or other entity for damages, arguing that the accident is a result of negligence.
A war-veteran-turned-truck driver Nico "Nick" Garcos (Richard Conte) arrives at home to find that his foreign-born father, a fruit farmer, has lost his legs and was forced to sell his truck. He learns that his father was crippled at the hands of an unscrupulous produce dealer in San Francisco, Mike Figlia (Lee J. Cobb). Garcos vows revenge.
The film tells the story of Simon Calmat (Vincent Lindon), a French swimming coach who is divorcing his wife Marion (Audrey Dana). Simon tries to help a young Iraqi-Kurd immigrant, Bilal Kayani (Firat Ayverdi), whose dream is to cross the English Channel from Calais in France to the United Kingdom by any means possible to be reunited with his girlfriend Mina (Derya Ayverdi). Meanwhile, Mina's father strongly opposes Bilal's plans as he wants to marry his daughter to her cousin who owns a restaurant. After being caught with other immigrants and returned to France, Simon gives him temporary refuge at his home after the young Bilal, nicknamed "Bazda" (runner, for his athletic abilities and love of football and Manchester United in particular) registers for swimming lessons, intending to train to be able to swim across the Channel. After police search Simon's apartment, Bilal goes on a final attempt and drowns 800 meters from the English coast while hiding from the coastguard. Simon then travels to inform Mina.
Los Angeles SWAT officers Jack Traven and Harry Temple thwart an attempt by a bomber to hold an elevator full of people for a $3 million ransom. They corner the bomber, but he grabs Harry. Jack shoots Harry in the leg, forcing the bomber to release him. He turns and runs around a corner, apparently dying in an explosion. Jack and Harry are praised by their superior, Lieutenant "Mac" McMahon.
The story takes place in June 1991 in Yugoslavia, only a few days before the outbreak of the Yugoslav War. Ratko (Srđan Todorović), a Bosnian Serb, leaves Belgrade prison and steals a red-coloured Mercedes-Benz truck. The fact that he's (almost pathologically) passionate about stealing trucks and driving them while at the same time being colour-blind brought him to prison in the first place. Suzana (Aleksandra Balmazović), an urban Belgrade girl, discovers she is pregnant and wants to do an abortion. As her father, who believes that the emerging chaos won't last, uses their money for a speculative investment, she decides to go to Dubrovnik to earn the money for abortion. After nearly running her over while she was hitch-hiking, Ratko decides to give her a lift.
Truck driver Jack Burton (Kurt Russell) and his friend, restaurant owner Wang Chi (Dennis Dun), go to the airport to pick up Wang's fiancée Miao Yin (Suzee Pai), who is arriving from China. A Chinese street gang, the Lords of Death, tries to kidnap another Chinese girl at the airport who is being met by her friend Gracie Law (Kim Cattrall), intending to sell her as a sex slave. After Jack intervenes, they take Miao Yin instead. In Jack's big-rig truck, he and Wang track the Lords of Death to the back alleys of Chinatown, where they find a funeral procession that quickly erupts into a street fight between the Chang Sing and Wing Kong, two ancient Chinese societies. When "The Three Storms" (Thunder, Rain, and Lightning) appear, slaughtering the Chang Sing, Jack tries to escape but runs over Lo Pan (James Hong), a powerful and legendary sorcerer, as well as the leader of the Wing Kong. Horrified, Jack exits his truck, only to find Lo Pan, who is merely annoyed. Wang hurriedly guides Jack through the alleys, escaping the carnage and mayhem, but Jack's truck is stolen.
Brothers Joe (George Raft) and Paul Fabrini (Humphrey Bogart) are independent truck drivers who make a meager living transporting goods. Joe convinces Paul to start their own small, one-truck business, staying one step ahead of loan shark Farnsworth (an uncredited Charles Halton), who is trying to repossess their truck.
Tom Yately, just released from prison, is determined to start a new life and he gets a job as a driver at Hawletts, a haulage company that transports loads of ballast gravel from a nearby quarry. The truck-drivers are offered bonuses by the agent Cartley for delivering their loads at dangerously high speeds along narrow roads. Tom is accepted by the other drivers except Red, the foreman and head driver and also a violent bully. Tom soon becomes friends with Gino, an Italian driver who is in love with Cartley's secretary Lucy. Red offers a cash bonus to any driver who can make more runs than him and Tom is determined to try.
Entrecroisées mais indépendantes, l'histoire d'une famille réunie pour l'enterrement d'un de ses jeunes membres, tué sur la route, et l'histoire d'un Algérien qui émigre en France et qui raconte dans une lettre à sa fille l'histoire biblique de Jonas.